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Inhibition of mouse TRPC4 expressed in HEK293 cells coexpressing M5 receptor assessed as reduction in TRPC4-mediated calcium influx by fluorescence method
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at mouse TRPC4 expressed in HEK293 cells coexpressing M5 receptor assessed as induction of TRPC4-mediated calcium influx by fluorescence method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of mouse TRPC4 by FLIPR assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of YFP-tagged mouse TRPC4 beta expressed in thapsigargin treated HEK293 cells co-expressing M3 receptor assessed as reduction in carbachol-induced calcium level by fluo-4 dye based fluorescence assay
Inhibition of mouse TRPC4 beta expressed in HEK293 cells co-expressing mu-opioid receptor assessed as reduction in DAMGO-induced membrane potential by FMP-2 dye based assay
Assay data:4 Active, 7 Tested
Inhibition of mouse TRPC4 beta expressed in HEK293 cells co-expressing mu-opioid receptor assessed as reduction in DAMGO-induced current by QPatch clamp assay
Inhibition of mouse TRPC4 beta expressed in HEK293 cells co-expressing mu-opioid receptor assessed as reduction in DAMGO-induced intracellular calcium level in presence of mu-opioid receptor agonist DAMGO by Fluo-4AM dye based fluorescence assay
Agonist activity at mouse TRPC4beta expressed in HEK293 cells co-expressing MOR assessed as increase in intracellular calcium level at 33 uM measured for 2.5 mins by Fluo-8-AM dye-based fluorescence assay
Assay data:4 Tested
Agonist activity at mouse TRPC4beta expressed in HEK293 cells co-expressing MOR assessed as induction of membrane depolarization at 33 uM measured for 2.5 mins by FLIPR membrane potential dye-based fluorescence assay
Inhibition of mouse TRPC4beta expressed in HEK293 cells co-expressing MOR assessed as decrease in DAMGO-evoked membrane depolarization at 22 uM preincubated for 2 mins followed by DAMGO addition measured for 2.5 mins by FLIPR membrane potential dye-based fluorescence assay relative to control
Assay data:2 Tested
Antagonist activity at mouse TRPC4beta expressed in HEK293 cells co-expressing MOR decrease in DAMGO-evoked intracellular calcium level by Fluo-8-AM dye-based fluorescence assay
Assay data:1 Active, 16 Tested
Mouse TRPC4 (Transient Receptor Potential channels)
Assay data:2 Active, 2 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Summary of extended characterization studies of small molecule TRPC4 channel inhibitors
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
SAR analysis for compounds that inhibit transient receptor potential cation channel C4 (TRPC4)
Assay data:6 Active, 21 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
SAR Analysis for the identification of selective inhibitors of the transient receptor potential cation channel C6 (TRPC6) in cells expressing TRPC4: C4 assay CRC 2
Assay data:16 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
SAR Analysis for the identification of selective inhibits of the transient receptor potential cation channel C4 (TRPC4): Automated Electrophysiology_2
Assay data:13 Active, 1 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
SAR Analysis for the identification of selective inhibitors of the transient receptor potential cation channel C6 (TRPC6) in cells expressing TRPC4: C4 assay CRC
Assay data:34 Tested
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