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Agonist activity at mouse LXRbeta
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Transactivation of LXR-alpha/beta in mouse RAW264.7 cells assessed as upregulation of ABCA1 mRNA expression at 10 to 50 uM after 3 hrs by RT-PCR method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of T0901317-induced LXR-alpha/beta transactivation in mouse RAW264.7 cells assessed as reduction in ABCA1 mRNA expression after 3 hrs by RT-PCR method
Inhibition of T0901317-induced LXR-alpha/beta transactivation in mouse RAW264.7 cells assessed as reduction in ABCA1 mRNA expression at 50 uM after 3 hrs by RT-PCR method relative to control
Inhibition of T0901317-induced LXR-alpha/beta transactivation in mouse RAW264.7 cells assessed as reduction in ABCA1 mRNA expression at 25 uM after 3 hrs by RT-PCR method relative to control
Inhibition of T0901317-induced LXR-alpha/beta transactivation in mouse RAW264.7 cells assessed as reduction in ABCA1 mRNA expression at 10 uM after 3 hrs by RT-PCR method
Agonist activity at mouse LXRbeta expressed in HEK293 cells co-expressing CMX-beta-galactosidase incubated for 16 hrs by luciferase reporter gene assay relative to T0901317
Assay data:4 Tested
Agonist activity at mouse LXRbeta expressed in HEK293 cells co-expressing CMX-beta-galactosidase incubated for 16 hrs by luciferase reporter gene assay
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Mouse Liver X receptor-beta (1H. Liver X receptor-like receptors)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Agonist activity at LXRbeta in mouse RAW264.7 cells assessed as induction of ABCA1 promoter activation at 1 uM after 24 hrs by Dual-Glo luciferase reporter gene assay relative to vehicle-treated control
Assay data:45 Tested
Agonist activity at LXRbeta in mouse RAW264.7 cells assessed as induction of ABCA1 promoter activation after 24 hrs by Dual-Glo luciferase reporter gene assay
Assay data:2 Tested
Agonist activity at LXRbeta in mouse RAW264.7 cells assessed as upregulation of ABCA1 protein expression at 1 uM after 18 to 48 hrs by Western blot analysis
Assay data:3 Active, 3 Tested
Agonist activity at LXRbeta in mouse RAW264.7 cells assessed as upregulation of ABCA1 protein expression after 18 to 48 hrs by Western blot analysis
Assay data:3 Tested
Agonist activity at LXRbeta in mouse BV2 cells assessed as upregulation of ABCA1 protein expression at 1 uM after 12 to 48 hrs by Western blot analysis
Agonist activity at LXRbeta in mouse BV2 cells assessed as upregulation of ABCA1 protein expression after 12 to 48 hrs by Western blot analysis
Agonist activity at LXRbeta in mouse BV2 cells assessed as upregulation of apoE protein expression at 0.1 uM after 48 hrs by Western blot analysis relative to vehicle-treated control
Agonist activity at LXRbeta in mouse BV2 cells assessed as upregulation of apoE protein expression at 1 uM after 48 hrs by Western blot analysis relative to vehicle-treated control
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