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Dual-Cell beta-Catenin Reporter Assay from US Patent US10202375: "N-pyridinyl acetamide derivatives as Wnt signalling pathway inhibitors"
Assay data:20 Active, 14 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of mouse wnt3a expressed in human MDA-MB-231 cells assessed as LEF1 level at 30 uM incubated for 24 mins by quantitative real-time PCR analysis relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of mouse wnt3a expressed in human MDA-MB-231 cells assessed as HPRT level at 30 uM incubated for 24 mins by quantitative real-time PCR analysis relative to control
Inhibition of mouse wnt3a expressed in human MDA-MB-231 cells assessed as LEF1 level at 10 uM incubated for 24 mins by quantitative real-time PCR analysis relative to control
Inhibition of mouse wnt3a expressed in human MDA-MB-231 cells assessed as LEF1 level at 3.3 uM incubated for 24 mins by quantitative real-time PCR analysis relative to control
Inhibition of mouse wnt3a expressed in human MDA-MB-231 cells assessed as cyclin D1 level at 30 uM incubated for 24 mins by quantitative real-time PCR analysis relative to control
Inhibition of mouse wnt3a expressed in human MDA-MB-231 cells assessed as cyclin D1 level at 10 uM incubated for 24 mins by quantitative real-time PCR analysis relative to control
Inhibition of mouse wnt3a expressed in human MDA-MB-231 cells assessed as cyclin D1 level at 3.3 uM incubated for 24 mins by quantitative real-time PCR analysis relative to control
Inhibition of mouse wnt3a expressed in human MDA-MB-231 cells assessed as Axin2 level at 30 uM incubated for 24 mins by quantitative real-time PCR analysis relative to control
Inhibition of mouse wnt3a expressed in human MDA-MB-231 cells assessed as Axin2 level at 10 uM incubated for 24 mins by quantitative real-time PCR analysis relative to control
Inhibition of mouse wnt3a expressed in human MDA-MB-231 cells assessed as Axin2 level at 3.3 uM incubated for 24 mins by quantitative real-time PCR analysis relative to control
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Inhibition of mouse Wnt3A signaling in human HEK293 cells after 1 day by super top flash luciferase reporter gene assay
Assay data:9 Active, 7 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
SAR analysis of small molecule antagonists of Gli-SUFU in a Wnt3a luminescent reporter assay
Assay data:4 Active, 3 Activity ≤ 1 µM, 60 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay
Assay data:233 Active, 28 Activity ≤ 1 µM, 344 Tested
Inhibition of Wnt3A lipidation in mouse L cell expressing Wnt3a and overexpressing porcn at 2 uM by detergent solubility fractionation assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Wnt3A palmitoylation in mouse L cell expressing Wnt3a and overexpressing porcn by detergent solubility fractionation assessed as [3H]palmitate incorporation at 2.5 uM by autoradiography method
Activation of mouse Wnt3a signaling expressed in HEK293 STF cells assessed as increase in transcriptional activity after 24 hrs by luciferase reporter gene-based lactate dehydrogenase assay
Assay data:4 Active, 4 Tested
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