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Inhibition of placental alpha-L-fucosidase (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
In Vitro Fucosidase Inhibition from US Patent US10308607: "Fucosidase inhibitors"
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Substrate activity at recombinant N-terminal GFP tagged human alpha L-fucosidase expressed in HEK293T cells assessed as de-fucosylation of N-glycan at 5 mg/ml measured after 21 hrs by LC/MS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Substrate activity at recombinant N-terminal GFP tagged human alpha L-fucosidase expressed in HEK293T cells assessed as de-fucosylation of N-glycan at 5 mg/ml measured after 7 hrs by LC/MS analysis
Substrate activity at recombinant N-terminal GFP tagged human alpha L-fucosidase expressed in HEK293T cells assessed as compound hydrolysis at 5 mg/ml measured after 60 mins by LC/MS analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Substrate activity at recombinant N-terminal GFP tagged human alpha L-fucosidase expressed in HEK293T cells assessed as formation of p-nitrophenyl products at 5 mM measured by UV spectrometer assay
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
Ratio of deoxyfuconojirimycin IC50 to compound IC50 for human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry
Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometry
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
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