BioAssay by Target (List) for Gene (Select 2534) - PubChem BioAssay - NCBI

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Select item 19564511.

Inhibition of His-tagged human recombinant FYN expressed in insect cells at 200 nM by Z'-lyte assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:1 Tested

AID:: 1956451

Summary Related BioAssays by Target

Select item 19490732.

Inhibition of FYN (unknown origin) by Ambit kinase assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:1 Tested

AID:: 1949073

Summary Related BioAssays by Target

Select item 19400103.

Inhibition of FYN (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1940010

Summary Related BioAssays by Target

Select item 19391294.

Inhibition of FYN (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:1 Activity ≤ 1 µM, 1 Tested

AID:: 1939129

Summary Related BioAssays by Target

Select item 19348515.

Inhibition of human partial length wild type Fyn (T243/L534) expressed in bacterial system at 1 uM by KINOMEscan analysis relative to control

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:1 Tested

AID:: 1934851

Summary Related BioAssays by Target

Select item 19322746.

Inhibition of FYN (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:1 Tested

AID:: 1932274

Summary Related BioAssays by Target

Select item 19196077.

Kinase Inhibition Assay from US Patent US11713306: "5-substituted difluoropiperidine compounds with blood-brain barrier penetrable capability"

Source:: BindingDB

Protein Targets:: Epidermal growth factor receptor; ...
Total:: 3

Assay data:39 Active, 39 Activity ≤ 1 µM, 39 Tested

AID:: 1919607

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19153838.

Selectivity interaction (Kinase panel (HTRF assay)) EUB0000221b FYN

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:1 Active, 1 Tested

AID:: 1915383

Summary Related BioAssays by Target

Select item 19136849.

Selectivity interaction (Z?-LYTE assay) EUB0000638a FYN

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:1 Tested

AID:: 1913684

Summary Related BioAssays by Target

Select item 191359410.

Selectivity interaction (HotSpot assay platform (Reaction Biology)) EUB0000632a FYN

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:1 Tested

AID:: 1913594

Summary Related BioAssays by Target

Select item 189994111.

Inhibition of human Fyn at 10 uM by radiometric kinase activity assay relative to control

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:1 Tested

AID:: 1899941

Summary PubMed Citation Related BioAssays by Target

Select item 189994012.

Inhibition of human Fyn at 0.1 uM by radiometric kinase activity assay relative to control

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:1 Tested

AID:: 1899940

Summary PubMed Citation Related BioAssays by Target

Select item 189993313.

Inhibition of from NanoLuc-fused Fyn (unknown origin) transfected in HEK293 cells using tracer K4 incubated for 1 hr by NanoBRET assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1899933

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 189993114.

Inhibition of human Fyn using Cdc2 peptide as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by radiometric scintillation assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1899931

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 189426615.

Inhibition of FynT (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1894266

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 187711216.

Inhibition of FYN in HEK293 cells up to 8 uM measured after 4 days by Western blot analysis

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:2 Tested

AID:: 1877112

Summary PubMed Citation Related BioAssays by Target

Select item 187628317.

Binding affinity to Fyn (unknown origin) assessed as dissociation constant

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1876283

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 184557018.

Inhibition of FYN (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1845570

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 183556519.

FYN DiscoveRx kinase panel

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:1 Tested

AID:: 1835565

Summary Related BioAssays by Target

Select item 183497520.

Fyn(h) Kinase panel

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:1 Tested

AID:: 1834975

Summary Related BioAssays by Target

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Target

Proteins (4)
BioAssays with protein sequences specified as targets
RNAi Target, Active (9)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (135)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (16)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (121)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (195)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (41)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (479)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (46)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (439)
BioAssays extracted from the literature
NIH MLP (3)
BioAssays deposited by the NIH Molecular Libraries Program
Other (82)
BioAssays deposited by other experimentalists

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