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Cross screening panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of GABAA receptor (unknown origin) upto 10000 nM
SummaryPubMed CitationRelated BioAssays by Target
Potentiation of NAS mediated GABA (unknown origin) tonic effect assessed as fold potentiation
Assay data:6 Tested
Positive allosteric modulator activity at human GABAA receptor measured by [35S]TBPS based functional assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of GABAA receptor (unknown origin) at 50 uM by radioligand receptor binding assay relative to control
Assay data:23 Tested
Inhibition of GABA-A receptor (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of GABAA alpha3 receptor (unknown origin)
Inhibition of GABAA receptor (unknown origin)
Assay data:9 Active, 4 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 10 Tested
Inhibition of human recombinant GABAA alpha3 receptor
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to human recombinant GABAA alpha3 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting analysis
Assay data:21 Active, 1 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay
Assay data:21 Active, 12 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 25 Tested
Inhibition of GABAA receptor (unknown origin) at 10 uM
Inhibition of GABAA receptors (unknown origin)
Binding affinity to GABAA receptor (unknown origin) at 10000 nM by radioligand displacement assay relative to control
Displacement of [3H]flunitrazepam from human recombinant alpha3beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand binding assay
Assay data:16 Active, 3 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 21 Tested
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