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Inhibition of sigma 2 receptor (unknown origin)
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant in presence of haloperidol measured for 120 mins by scintillation counting analysis
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant in presence of (+)-SKF10047 by radioligand binding assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant incubated for 120 mins in presence of (+)-SKF10047 by radioligand binding assay
Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested
Binding affinity to sigma 2 receptor in human MCF7 cells assessed as displacement of compound by measuring inhibition constant of 2-(3-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-5-methoxy-3,4-dihydroisoquinolin-1(2H)-one incubated for 120 mins by saturation binding assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to sigma 2 receptor in human MCF7 cells assessed as displacement of compound by measuring inhibition constant of DTG incubated for 120 mins by saturation binding assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to sigma 2 receptor in human MCF7 cells assessed as increase in fluorescent intensity pretreated with (+)-pentazocine for 60 mins followed by compound addition incubated for 45 mins by flow cytometric analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to sigma 2 receptor (unknown origin) assessed as inhibition constant
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Displacement of [3H]DTG from sigma-2 receptor in HEK293 cell membrane assessed as inhibition constant
Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested
Inhibition of Sigma2 receptor (unknown origin) at 10 uM
Binding affinity to sigma 2 receptor (unknown origin) expressed in human RT-4 cells
Binding affinity to sigma 2 receptor (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Displacement of [H3]DTG from sigma 2 receptor (unknown origin) by competition binding assay
Assay data:7 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Binding affinity to human sigma 2 receptor
Assay data:5 Active, 4 Activity ≤ 1 µM, 7 Tested
In-Vitro Binding Assay from US Patent US20230390272: "USE OF PRIDOPIDINE AND ANALOGS FOR THE TREATMENT OF ANXIETY AND DEPRESSION"
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000103c TMEM97
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000209b TMEM97
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000264b TMEM97
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