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Inhibitory activity against Growth factor receptor bound protein 2
Assay data:4 Active, 3 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
In vitro binding affinity in whole cells for Grb2 SH2 domain
Assay data:1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
In vitro binding affinity in extracellular ELISA-based assay for Grb2 SH2 domain
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Dissociation constant of compound was determined from affinity of compound towards Growth factor receptor bound protein 2 measured by fluorescence; Non-detectable
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Dissociation constant of compound was determined from affinity of compound towards Growth factor receptor bound protein 2 measured by fluorescence
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Compound was evaluated for the inhibitory activity against Growth factor receptor bound protein 2 SH2 at a concentration of 100 uM
Assay data:3 Tested
In vitro binding to Growth factor receptor bound protein 2
Inhibition of Growth factor receptor bound protein 2 SH2 domain binding in plasmon resonance assay
Assay data:1 Tested
Assay data:3 Active, 1 Activity ≤ 1 µM, 4 Tested
Inhibition of Growth factor receptor bound protein 2 SH2 domain binding in ELISA
Assay data:3 Active, 2 Activity ≤ 1 µM, 5 Tested
In vitro binding affinity for Grb2 SH2 domain
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of Growth factor receptor bound protein 2 SH2 domain in extracellular binding assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of binding to Growth factor receptor bound protein 2 SH2 domain
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of Grb2 SH2 domain binding to erbB-2
Assay data:1 Activity ≤ 1 µM, 1 Tested
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Competitive binding affinity against Growth factor receptor bound protein 2 was assessed using SHC(pTyr-317) phospopeptide in biacore surface plasmon resonance (SPR) method
Assay data:4 Active, 2 Activity ≤ 1 µM, 7 Tested
Inhibition of Growth factor receptor bound protein 2 SH2 domain binding to phospho-EGFR by ELISA
Assay data:4 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
The compound was tested on a LS250B Perkin-Elmer fluorimeter for Growth factor receptor bound protein 2 equilibrium constant(Kd) by the Michaelis-Menten type curve-fitting equation
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Dissociation constant for binding to SH2 domain of Growth factor receptor bound protein 2, Grb2
In vitro binding affinity for growth factor receptor bound protein 2 SH2 domain from human breast cancer cells
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
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