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Inhibition of GST-tagged HRAS (1 to 166 residues) (unknown origin) assessed as inhibition of mSOS1 mediated nucleotide exchange by [35S]GTPgammaS based liquid scintillation counting method
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human H-ras
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of HRAS (unknown origin) farnesylation
Inhibition of HRAS (unknown origin) transfected in BALB/c nude mouse incubated for 3 days measured by immunoblot analysis
Binding affinity to HRAS (unknown origin) assessed as inhibition constant
Inhibition of human p21 h-RAS assessed as reduction in C-Cdc25 stimulated nucleotide exchange by luminescence spectrometer based analysis
Cellular assay: Active RAS (KRAS, HRAS, NRAS)in Calu-1 cells (KRASwt)
Assay data:1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
Cellular assay: Active RAS (KRAS, HRAS, NRAS) in HeLa cells (KRASwt)
Inhibition of GFP-tagged HRAS G12V mutant (unknown origin) expressed in MDCK cells assessed as reduction in ERK phosphorylation level incubated for 48 hrs by Western blot analysis
Assay data:1 Tested
Inhibition of GFP-tagged HRAS G12V mutant (unknown origin) expressed in MDCK cells assessed as reduction in Akt phosphorylation level incubated for 48 hrs by Western blot analysis
Inhibition of GFP-tagged HRAS G12V mutant (unknown origin) expressed in MDCK cells cotransfected with mCherry-CAXX assessed as effect on HRAS G12V-plasma membrane dissociation incubated for 48 hrs by quantitative confocal microscopic method
Binding affinity to NT-647 cysteine-labeled and N-terminal-GST-tagged recombinant human H-Ras (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) at up to 100 uM by microscale thermophoresis analysis
Assay data:3 Tested
SummaryRelated BioAssays by Target
Binding affinity to NT-647 cysteine-labeled and N-terminal-GST-tagged recombinant human H-Ras (1 to 166 residues) expressed in Escherichia coli BL21 (DE3) at 0.006 to 100 uM by microscale thermophoresis analysis
Inhibition GST-tagged recombinant HRAS G12V mutant (1 to 166 amino acids) (unknown origin) expressed in Escherichia coli C41(DE3) by SPR assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of HRAS G12V mutant (unknown origin) expressed in mouse NIH/3T3 cells assessed as reduction in MAPK phosphorylation up to 100 nM measured after 2 hrs by Western blot analysis
Inhibition of HRAS G12V mutant (unknown origin) expressed in mouse NIH/3T3 cells assessed as reduction in cell proliferation up to 100 nM supplemented with fresh medium containing compound for every 2 to 3 days measured at 2 days interval during compound dosing
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Human HRAS (RAS subfamily)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
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