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Inhibition Assay from Article 10.1080/14756360109162353: "Inhibitors of human and rat testes microsomal 17beta-hydroxysteroid dehydrogenase (17beta-HSD) as potential agents for prostatic cancer."
Assay data:5 Active, 14 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human 17-beta-HSD3 expressed in LNCaP cells assessed as reduction in oxidation of [14C]-4-androstene-3,17-dione to [14C]-testosterone at 3 uM incubated for 1 hr by thin layer chromatography
Assay data:7 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human 17-beta-HSD3 expressed in LNCaP cells assessed as reduction in oxidation of [14C]-4-androstene-3,17-dione to [14C]-testosterone at 0.3 uM incubated for 1 hr by thin layer chromatography
Potency index, ratio of RM-532-105 IC50 to test compound IC50 for 17beta-HSD3 (unknown origin) expressed in human LNCAP cells
Assay data:5 Tested
Inhibition of 17beta-HSD3 (unknown origin) expressed in human LNCAP cells assessed as reduction in [14C]-testosterone formation from [14C]-4-androstene-3,17-dione measured after 1 hr
Assay data:11 Active, 10 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of 17beta-HSD3 (unknown origin) expressed in human LNCAP cells assessed as reduction in [14C]-testosterone formation from [14C]-4-androstene-3,17-dione at 1 uM measured after 1 hr relative to control
Assay data:17 Tested
Inhibition of 17beta-HSD3 (unknown origin) expressed in human LNCAP cells assessed as reduction in [14C]-testosterone formation from [14C]-4-androstene-3,17-dione at 0.5 uM measured after 1 hr relative to control
Inhibition of 17beta-HSD3 (unknown origin) expressed in human LNCAP cells assessed as reduction in [14C]-testosterone formation from [14C]-4-androstene-3,17-dione at 0.1 uM measured after 1 hr relative to control
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of 17-beta-HSD3 (unknown origin) expressed in human LNCaP cells using [14C]-4-androstene-3,17-dione as substrate assessed as reduction of [14C]-testosterone level at 0.1 to 1 uM after 1 hr by TLC method
Assay data:3 Tested
Inhibition of 17-beta-HSD3 (unknown origin) expressed in human LNCaP cells using [14C]-4-androstene-3,17-dione as substrate assessed as reduction of [14C]-testosterone level after 1 hr by TLC method
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of 17betaHSD3 (unknown origin) transfected in HEK293 cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of 17betaHSD3 (unknown origin) transfected in human LNCAP cells assessed as conversion of [14C]-4-androstene-3,17-dione into [14C]-testosterone after 3 hrs
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of 17beta-HSD3 (unknown origin) expressed in human LNCaP cells using [14C]-4-androstene-3,17-dione as substrate at 0.5 uM after 3 hrs
Assay data:1 Tested
Inhibition of 17beta-HSD3 (unknown origin) expressed in human LNCaP cells using [14C]-4-androstene-3,17-dione as substrate at 1 uM after 3 hrs
Assay data:2 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Inhibition of 17beta-HSD3 (unknown origin) expressed in intact HEK293 cells assessed as residual enzyme activity at 20 uM
Assay data:10 Tested
Inhibition of 17beta-HSD3 (unknown origin) expressed in intact HEK293 cells
Assay data:3 Active, 3 Tested
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
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