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Binding affinity towards human HTR6 in an in vitro assay with cellular components measured by membrane filtration
Assay data:27 Active, 15 Activity ≤ 1 µM, 148 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human 5-HT6 receptor at 1 uM relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H]-LSD from human 5-HT6 receptor expressed in HEK cell membrane incubated for 60 mins by microplate beta scintillation counting analysis
Assay data:14 Active, 9 Activity ≤ 1 µM, 14 Tested
Displacement of [3H]-LSD from human 5-HT6 receptor expressed in HEK cell membrane at 10 uM incubated for 60 mins by microplate beta scintillation counting analysis
Assay data:5 Tested
Antagonist activity at 5-HT6 receptor (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constant
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of 5HT6 receptor (unknown origin) at 10 uM
Radioligand Binding Assay from US Patent US11642336: "5-HT2A agonists for use in treatment of depression"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Displacement of [3H]-LSD from human 5-HT6R expressed in HEK293 cells assessed as binding constant by radioligand binding assay
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Displacement of [3H]-LSD from human 5-HT6R expressed in HEK293 cells by radioligand binding assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Displacement of [3H]LSD from 5-HT6R (unknown origin) expressed in HEK293 cells assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Displacement of LSD from recombinant human 5-HT6R assessed as inhibition constant
Displacement of [125I]cAMP-tracer from 5-HT6R in human HeLa cells assessed as measuring cAMP level incubated for 15 mins by radioimmunoassay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Displacement of [3H] LSD from 5-HT6R in HEK293 cells assessed as inhibition constant incubated for 1 hr in presence of haloperidol by microbeta plate reader analysis
Displacement of [3H] LSD from 5-HT6R in human HeLa cells assessed as inhibition constant incubated for 120 mins in presence of methiothepin by scintillation counting method
Displacement of [3H] LSD from human 5-HT6R expressed in HEK293 cell membrane assessed as inhibition constant by competition binding assay
Displacement of [3H] LSD from recombinant human 5-HT6R expressed in HEK293 cells assessed as inhibition constant
Assay data:12 Active, 5 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 12 Tested
Selectivity interaction (PRESTO-Tango GPCR-ome screening) EUB0000353a HTR6
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000353a HTR6
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