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Induction of microtubule depolymerization in human SGC7901 cells assessed as change in microtubule morphology at 2 fold antiproliferative IC50 measured after 24 hrs by DAPI staining based fluorescence microscopy
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of tubulin polymerization in human RS4:11 cells at 300 nM by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of tubulin polymerization in human CEM cells at 300 nM by Western blot analysis
Induction of microtubule network depolymerization in human HeLa cells assessed as formation of condensed chromosomes at 500 nM incubated for 18 hrs by DAPI staining based fluorescence microscopic method
Assay data:1 Active, 1 Tested
Induction of microtubule fragmentation in human NCI-H1975 cells at 50 nM incubated for 12 hrs by DAPI staining based laser confocal microscopic method
Induction of microtubule fragmentation in human NCI-H1975 cells at 140 nM incubated for 12 hrs by DAPI staining based laser confocal microscopic method
Induction of microtubule fragmentation in human NCI-H1975 cells at 30 nM incubated for 12 hrs by DAPI staining based laser confocal microscopic method
Induction of tubulin depolymerization in human HeLa cells after 24 hrs by DAPI staining based fluorescence microscopic analysis
Inhibition of [3H]colchicine binding to tubulin (unknown origin) measured after 10 mins by beckman scintillation counting method relative to control
Inhibition of [3H]colchicine binding to tubulin (unknown origin) at 5 uM measured after 10 mins by beckman scintillation counting method relative to control
Assay data:22 Tested
Inhibition of [3H]colchicine binding to tubulin (unknown origin) at 1 uM measured after 10 mins by beckman scintillation counting method relative to control
Assay data:9 Tested
Inhibition of [3H]colchicine binding to tubulin (unknown origin) at 0.5 uM measured after 10 mins by beckman scintillation counting method relative to control
Inhibition of human tubulin polymerization in HMEC1 cells assessed as induction of tubulin polymerization destabilization at 30 uM incubated for 3 hrs and measured after 90 mins by turbidimetric assay
Assay data:10 Active, 10 Tested
Inhibition of tubulin polymerization (unknown origin) at 3 uM incubated for 1 hr by fluorescence assay relative to control
Assay data:3 Tested
Inhibition of microtubule formation in human SGC7901 cells at 2 fold IC50 concentration measured after 24 hrs by DAPI staining based fluorescence microscopy
Inhibition of microtubule formation in human SGC7901 cells assessed as mitotic catastrophe at 2 fold IC50 concentration measured after 24 hrs by DAPI staining based fluorescence microscopy
Inhibition of tubulin polymerization in human HL60 cells at 300 nM by Western blot analysis
Inhibition of tubulin polymerization in human HeLa cells assessed as cellular microtubule disorganization and H3 phosphorylation at 500 nM after 24 hrs by immunofluorescence based confocal microscopy
Inhibition of tubulin polymerization in human HeLa cells assessed as contracted and rounded cells with disordered abnormal spindles and chromosomal misalignment at 500 nM after 24 hrs by immunofluorescence based confocal microscopy
Assay data:4 Active, 4 Tested
Ratio of Kd for colchicine to Kd for test compound for tubulin (unknown origin) by surface plasmon resonance analysis
Assay data:2 Tested
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