Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
ADP-Glo Kinase Assay from US Patent US20240109890: "BRIDGED HETEROCYCLYL-SUBSTITUTED PYRIMIDINE COMPOUNDS, PREPARATION METHOD AND MEDICAL USE THEREOF"
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biochemical JAK Kinase Assays from US Patent US20240092758: "IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS"
Assay data:392 Active, 381 Activity ≤ 1 nM, 392 Activity ≤ 1 µM, 392 Tested
In Vitro Test of Activities of Jak1, Jak2, Jak3, Tyk2 Kinases from US Patent US11919896: "[1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and use thereof"
Assay data:34 Active, 34 Activity ≤ 1 µM, 34 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro JAK Kinase Assay from US Patent US11918581: "Combination therapy comprising JAK pathway inhibitor and rock inhibitor"
Assay data:26 Active, 26 Activity ≤ 1 µM, 26 Tested
In Vitro JAK Kinase Assay from US Patent US20240058343: "TREATMENT OF URTICARIA USING JAK INHIBITORS"
NanoBRET assay (JAK1, SGC Frankfurt)
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of JAK1 (unknown origin) at 1 uM relative to control
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Assay data:1 Tested
Inhibition of JAK1/3 dependent IL-2 stimulated STAT5 phosphorylation in CD3-positive T cells (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of JAK1 JH2 (unknown origin) at 10 uM by DiscoverX KINOMEscan relative to control
Inhibition of JAK (unknown origin)
Assay data:5 Active, 5 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of JAK1 (unknown origin) by Ambit kinase assay
Inhibition of JAK1/JAK3 in human M07E cells assessed as reduction of IL-15 stimulated STAT phosphorylation preincubated for 30 mins followed by IL-15 stimulation for 15 mins by flow cytometry method
Assay data:4 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of GST-fused JAK1 (866 to 1154 residues) (unknown origin) using FITC-AhxKKSRGDYMTMQIG-NH2 peptide as substrate incubated for 60 mins in presence of ATP by Janus kinase assay
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of JAK1/JAK3 in human blood assessed as reduction of IL-2 stimulated STAT phosphorylation preincubated for 30 mins followed by IL-2 stimulation for 15 mins by flow cytometry method
Assay data:6 Active, 4 Activity ≤ 1 µM, 8 Tested
Inhibition of JAK1/TYK2 in human M07E cells assessed as reduction of IFN alpha stimulated STAT phosphorylation preincubated for 30 mins followed by IFN alpha stimulation for 15 mins by flow cytometry method
Assay data:7 Active, 7 Activity ≤ 1 µM, 8 Tested
Inhibition of JAK1 (unknown origin)
Inhibition of JAK1 (unknown origin) assessed as inhibition constant
Competitive inhibition of JAK1 (unknown origin) in the presence of ATP by JAK radiometric filter binding kinase assay
Inhibition of human JAK1 kinase domain incubated for 1 hrs in the presence of ATP by spectrophotometric analysis
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on