BioAssay by Target (List) for Gene (Select 387893) - PubChem BioAssay - NCBI

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Select item 19153771.

Selectivity interaction (Methyltransferase panel (Scintillation proximity assay (SPA))) EUB0000212b SETD8

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:1 Tested

AID:: 1915377

Summary Related BioAssays by Target

Select item 19153502.

Selectivity interaction (Methyltransferase panel) EUB0000196bCl SETD8

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:1 Tested

AID:: 1915350

Summary Related BioAssays by Target

Select item 19152813.

Selectivity interaction (Methyltransferase panel (radioactive enzyme assay)) EUB0000216b SETD8

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:1 Tested

AID:: 1915281

Summary Related BioAssays by Target

Select item 19152594.

Selectivity interaction (HMT panel) EUB0000194b SETD8

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:1 Tested

AID:: 1915259

Summary Related BioAssays by Target

Select item 19143675.

Selectivity interaction (Protein methyltransferase panel (activity assay)) EUB0000211b SETD8

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:1 Tested

AID:: 1914367

Summary Related BioAssays by Target

Select item 18858396.

Inhibition of human SET8 at 10 uM by radioisotope-based filter binding assay

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:1 Tested

AID:: 1885839

Summary PubMed Citation Related BioAssays by Target

Select item 18830867.

Inhibition of recombinant human his-tagged SETD8 (190 to 352 residues) at 1 to 10 uM incubated for 60 mins in presence of [3H]-SAM by hotspot assay

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:1 Tested

AID:: 1883086

Summary PubMed Citation Related BioAssays by Target

Select item 18742138.

Inhibition of SETD8 (unknown origin) at 1 uM using 3H-SAM as a substrate relative to control

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:1 Tested

AID:: 1874213

Summary PubMed Citation Related BioAssays by Target

Select item 18684989.

Inhibition of SETD8 (unknown origin) using [3H]SAM and HeLa nucleosomes as substrates incubated for 1 hr

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:1 Active, 1 Activity ≤ 1 µM, 6 Tested

AID:: 1868498

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 186849710.

Inhibition of SETD8 (unknown origin) using [3H]SAM and HeLa nucleosomes as substrates at 100 uM incubated for 1 hr relative to control

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:6 Tested

AID:: 1868497

Summary PubMed Citation Related BioAssays by Target

Select item 186482011.

Inhibition of human recombinant N-terminal his-tagged SET8 (190 to 352 residues) expressed in Escherichia coli at 50 uM in presence of [3H]-SAM by scintillation/filter plate assay relative to control

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:1 Tested

AID:: 1864820

Summary PubMed Citation Related BioAssays by Target

Select item 186478212.

Inhibition of human recombinant N-terminal his-tagged SET8 (190 to 352 residues) expressed in Escherichia coli at 10 uM in presence of [3H]-SAM by scintillation/filter plate assay

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:1 Tested

AID:: 1864782

Summary PubMed Citation Related BioAssays by Target

Select item 181188913.

Inhibition of SET8 (unknown origin) assessed as effect on H4K20 methylation incubated for 30 mins by Alphascreen assay

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:1 Tested

AID:: 1811889

Summary PubMed Citation Related BioAssays by Target

Select item 180850514.

Inhibition of SETD8 (unknown origin) at 1 to 10 uM

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:2 Tested

AID:: 1808505

Summary PubMed Citation Related BioAssays by Target

Select item 180269115.

HMT Assay from Article 10.1038/nchembio.2304: "An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED."

Source:: BindingDB

Protein Targets:: 5-hydroxytryptamine receptor 1A; ...
Total:: 68

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1802691

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 177428616.

Inhibition of SET8 (unknown origin) at 10 uM using SAM as substrate measured up to 960 mins by AlphaScreen microplate reader assay relative to control

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:1 Tested

AID:: 1774286

Summary PubMed Citation Related BioAssays by Target

Select item 177283817.

Inhibition of SET8 (unknown origin)-mediated H4K20 methylation using histone H4 and SAM as substrate incubated for 30 mins by AlphaScreen assay

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:1 Tested

AID:: 1772838

Summary PubMed Citation Related BioAssays by Target

Select item 172589818.

Inhibition of recombinant human GST-tagged SETD8 (195 to 352 residues) expressed in Escherichia coli using nucleosome as substrate at 10 uM by radiometric HotSpot assay relative to control

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:1 Tested

AID:: 1725898

Summary PubMed Citation Related BioAssays by Target

Select item 167920819.

Inhibition of wild type SETD8 catalytic domain (unknown origin) (234 to 380 residues) expressed in Escherichia coli assessed as compound-adduct dimer formation by measuring residual activity at 20 to 200 uM using varying levels of biotinylated H4 (1 to 24) peptide substrate measured after 1 hr in presence of [3H-SAM] by scintillation counting assay

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:1 Tested

AID:: 1679208

Summary PubMed Citation Related BioAssays by Target

Select item 167920720.

Inhibition of wild type SETD8 catalytic domain (unknown origin) (234 to 380 residues) expressed in Escherichia coli assessed as compound-adduct monomer formation by measuring residual activity at 20 to 200 uM using varying levels of biotinylated H4 (1 to 24) peptide substrate measured after 1 hr in presence of [3H-SAM] by scintillation counting assay

Source:: ChEMBL

Protein Target:: N-lysine methyltransferase KMT5A

Assay data:1 Tested

AID:: 1679207

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (8)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (29)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (9)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (33)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (11)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (74)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (15)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (69)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (19)
BioAssays deposited by other experimentalists

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