BioAssay by Target (List) for Gene (Select 4067) - PubChem BioAssay - NCBI

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Select item 6671121.

Inhibition of LYN incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Active, 1 Tested

AID:: 667112

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 6912932.

Inhibition of LynB at 1 uM

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Tested

AID:: 691293

Summary PubMed Citation Related BioAssays by Target

Select item 6912923.

Inhibition of Lyn at 1 uM

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Tested

AID:: 691292

Summary PubMed Citation Related BioAssays by Target

Select item 6872104.

Inhibition of LYN A after 5 mins

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Active, 1 Tested

AID:: 687210

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 6872095.

Inhibition of LYN B after 5 mins

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Active, 1 Tested

AID:: 687209

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 6782226.

Inhibition of human Lyn at 1 uM

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Tested

AID:: 678222

Summary PubMed Citation Related BioAssays by Target

Select item 6718727.

Inhibition of LYN

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 671872

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 6716148.

Inhibition of LYN assessed as remaining enzyme activity at 10 uM

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Tested

AID:: 671614

Summary PubMed Citation Related BioAssays by Target

Select item 6709859.

Inhibition of LYN

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Tested

AID:: 670985

Summary PubMed Citation Related BioAssays by Target

Select item 67014110.

Inhibition of Lyn A using ATP preincubated with compound for 5 mins measured after 10 mins

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Active, 1 Tested

AID:: 670141

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 67013811.

Inhibition of Lyn B using ATP preincubated with compound for 5 mins measured after 10 mins

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Active, 1 Tested

AID:: 670138

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 69663712.

Inhibition of Lyn A at 1 uM

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Tested

AID:: 696637

Summary PubMed Citation Related BioAssays by Target

Select item 66711113.

Inhibition of LYN at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Tested

AID:: 667111

Summary PubMed Citation Related BioAssays by Target

Select item 66633814.

Inhibition of human Lyn assessed as remaining activity at 0.8 uM after 40 mins by scintillation counting

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:2 Tested

AID:: 666338

Summary PubMed Citation Related BioAssays by Target

Select item 66069915.

Inhibition of Lyn at 2 uM

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Tested

AID:: 660699

Summary PubMed Citation Related BioAssays by Target

Select item 65659316.

Inhibition of human Lyn

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 656593

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 65659017.

Inhibition of human Lyn at 1 uM

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Tested

AID:: 656590

Summary PubMed Citation Related BioAssays by Target

Select item 65550718.

Inhibition of LYNb at 10 uM

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Tested

AID:: 655507

Summary PubMed Citation Related BioAssays by Target

Select item 65550619.

Inhibition of LYNa at 10 uM

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lyn

Assay data:1 Tested

AID:: 655506

Summary PubMed Citation Related BioAssays by Target

Select item 65181120.

Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:9227 Active, 64752 Tested

AID:: 651811

Summary PubMed Citation

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Target

Proteins (2)
BioAssays with protein sequences specified as targets
RNAi Target, Active (9)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (186)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (24)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (152)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (251)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (619)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (45)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (567)
BioAssays extracted from the literature
NIH MLP (2)
BioAssays deposited by the NIH Molecular Libraries Program
Other (94)
BioAssays deposited by other experimentalists

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