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Inhibition of TGF-beta induced Smad2/3 signaling in human HepG2 cells harboring pRL-EF1alpha, (CAGA)9x-MLP-Luc plasmid assessed as luciferase activity incubated for 24 hrs by Promega reporter rene assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of TGF-beta1-induced Smad2/3 phopshorylation in human MDA-MB-231 cells at 2 uM measured after 30 mins by Western blot analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of TGF-beta1 induced SMAD2/3 phosphorylation in human LX2 cells at 3 to 10 uM incubated for 24 hrs by Western blot analysis
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of TGF-beta induced SMAD2 phosphorylation in human A549 cells at 5 to 10 uM pretreated with compound for 2 hrs followed by TGF-beta stimulation by Western blot analysis
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of TGF-beta1-induced Smad2 phosphorylation in human A549 cells at 2.5 to 3 uM for 2 hrs followed by TGF-beta1 stimulation for 24 hrs by Western blot method
Assay data:1 Tested
Inhibition of TGFbeta1-induced SMAD2 phosphorylation in human SNU182 cells at 20 to 40 uM preincubated for 2 hrs followed by TGFbeta1 addition measured after 48 hrs in presence of (E)-1-(9-Ethyl-9H-carbazol-3-yl)-5-(4-hydroxy-3-methoxyphenyl)pent-1-en-3-one by Western blot method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of TGFbeta1-induced SMAD2 phosphorylation in human SNU182 cells at 20 to 40 uM preincubated for 2 hrs followed by TGFbeta1 addition measured after 48 hrs in presence of zingerone by Western blot method
TGF-beta/Smad small molecule agonists, qHTS assay: Summary
Assay data:8 Active, 2 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
TGF-beta/Smad small molecule antagonists, qHTS assay: Summary
Assay data:542 Active, 9667 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay to identify small molecule antagonists of the TGF-beta/Smad signaling pathway
Assay data:54 Active, 39 Activity ≤ 1 µM, 9667 Tested
qHTS assay to identify small molecule agonists of the TGF-beta/Smad signaling pathway
Assay data:13 Active, 24 Activity ≤ 1 µM, 9667 Tested
Inhibition of TGF-beta1-induced Smad2/3 phosphorylation in human LX2 cells at 10 uM after 1 hr by Western blot analysis
Inhibition of TGF-beta1-induced Smad2/3 phosphorylation in human LX-2 cells after 1 hr by Western blot analysis
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (SW620)
Assay data:15 Active, 794 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (SNUC5)
Assay data:11 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (HCT15)
Assay data:18 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (CAR1)
Assay data:9 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (HT55)
Assay data:20 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (RCM1)
Assay data:13 Active, 794 Tested
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