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Inhibition of TGF-beta induced Smad2/3 signaling in human HepG2 cells harboring pRL-EF1alpha, (CAGA)9x-MLP-Luc plasmid assessed as luciferase activity incubated for 24 hrs by Promega reporter rene assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of TGF-beta1-induced Smad2/3 phopshorylation in human MDA-MB-231 cells at 2 uM measured after 30 mins by Western blot analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of TGF-beta1 induced SMAD3 phosphorylation in human LX2 cells by Western blot analysis
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of TGF-beta1 induced SMAD2/3 phosphorylation in human LX2 cells at 3 to 10 uM incubated for 24 hrs by Western blot analysis
Inhibition of SMAD3 (unknown origin) phosphorylation transfected in NIH3T3-pCAGA12-Luc cells cotransfected with firefly luciferase at 5 uM by CAGA-based luciferase reporter assay relative to control
Assay data:26 Tested
Inhibition of SMAD3 (unknown origin) phosphorylation transfected in NIH3T3-pCAGA12-Luc cells cotransfected with firefly luciferase at 10 uM by CAGA-based luciferase reporter assay relative to control
Assay data:27 Tested
Inhibition of SMAD3 (unknown origin) phosphorylation transfected in NIH3T3-pCAGA12-Luc cells cotransfected with firefly luciferase by CAGA-based luciferase reporter assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of TGF-beta induced SMAD3 phosphorylation in human A549 cells at 5 to 10 uM pretreated with compound for 2 hrs followed by TGF-beta stimulation by Western blot analysis
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of TGF-beta1/smad3 signaling pathway in human HFL cells assessed as decrease in smad3 phosphorylation at 10 uM after 30 mins by Western blot analysis
Inhibition of TGF-beta1/smad3 signaling pathway in human HFL cells assessed as decrease in Col1 protein expression level at 10 uM after 24 hrs by Western blot analysis
Inhibition of TGF-beta1/smad3 signaling pathway in human HFL cell extract assessed as decrease in alpha-SMA protein expression at 10 uM after 24 hrs by Western blot analysis
TGF-beta/Smad small molecule agonists, qHTS assay: Summary
Assay data:8 Active, 2 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
TGF-beta/Smad small molecule antagonists, qHTS assay: Summary
Assay data:542 Active, 9667 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay to identify small molecule antagonists of the TGF-beta/Smad signaling pathway
Assay data:54 Active, 39 Activity ≤ 1 µM, 9667 Tested
qHTS assay to identify small molecule agonists of the TGF-beta/Smad signaling pathway
Assay data:13 Active, 24 Activity ≤ 1 µM, 9667 Tested
Inhibition of TGF-beta1-induced Smad2/3 phosphorylation in human LX2 cells at 10 uM after 1 hr by Western blot analysis
Assay data:1 Tested
Inhibition of TGF-beta1-induced Smad2/3 phosphorylation in human LX-2 cells after 1 hr by Western blot analysis
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
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