Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Displacement of [11C]PBB3 in human brain tau incubated for 30 mins by radioligand binding assay relative to control
Assay data:22 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [11C]PBB3 in human brain tau incubated for 30 mins by radioligand binding assay
Assay data:18 Active, 1 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of tau 4R1N phosphorylation (unknown origin) at S396 residue transfected in human U2OS cells coexpressing GFP-tagged beta catenin incubated overnight by high content imaging assay
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
Inhibition of tau phosphorylation (unknown origin)
Assay data:68 Active, 1 Activity ≤ 1 nM, 60 Activity ≤ 1 µM, 68 Tested
Inhibition of Tau (unknown origin) phosphorylation
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of tau (unknown origin) at 5 uM relative to control
Assay data:4 Tested
Inhibition of tau in human LA-N-5 cells assessed as reduction in 4R/3R ratio
Assay data:1 Tested
Binding affinity to tau (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of tau (unknown origin)
Kinase assay from US Patent US10774086: "GSK-3 inhibitors"
Assay data:44 Active, 28 Activity ≤ 1 nM, 44 Activity ≤ 1 µM, 44 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Fluorescence-Based Recombinant Tau Binding Assay from US Patent US11642413: "Compounds for degrading Tau protein aggregates and uses thereof"
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Inhibition of heparin-induced tau protein (unknown origin) aggregation at 100 uM incubated for 3 days by Thioflavin T fluorescence assay
Assay data:3 Tested
Binding affinity to N-terminal His-tagged recombinant human Tau40 expressed in Escherichia coli Rosetta (DE3) assessed as dissociation constant incubated for 0.5 hrs by fluorescence polarization assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to tau K18 domain (unknown origin) assessed as cysteine labelling at 250 uM incubated for 18 hrs by 15N-HSQC NMR spectroscopy
Inhibition of tau K18 domain (unknown origin) assessed as inhibition of heparin-induced aggregation by measuring increase in brightness by transmission electron microscopy
Assay data:3 Active, 3 Tested
Inhibition of tau K18 domain (unknown origin) assessed as inhibition of heparin-induced aggregation by measuring reduction in intensity at 215 nm with random coil conformation by CD spectrometry
Covalent binding affinity to tau K18 domain monomer (unknown origin) assessed as labelling at Cys322 residue incubated for 24 hrs and measured following trypsin digestion by LC-MS/MS analysis
Assay data:2 Active, 2 Tested
Covalent binding affinity to tau K18 domain monomer (unknown origin) assessed as labelling at Cys291 residue incubated for 24 hrs and measured following trypsin digestion by LC-MS/MS analysis
Inhibition of tau K18 domain (unknown origin) assessed as inhibition of heparin-induced aggregation by measuring protein aggregation rate at 1000 uM by thioflavin-T fluorescence assay relative to control
Inhibition of tau K18 domain (unknown origin) assessed as inhibition of heparin-induced aggregation by measuring protein aggregation rate at 500 uM by thioflavin-T fluorescence assay relative to control
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on