BioAssay by Target (List) for Gene (Select 4255) - PubChem BioAssay - NCBI

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Select item 1474691.

In vitro inhibitory activity of compound against AGT (O6-alkylguanine-DNA alkyltransferase) at a concentration of 0.1 uM using breast cancer MCF-7 cells, expressed as Fmol O6-MeG removed/mg of protein

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:1 Tested

AID:: 147469

Summary PubMed Citation Related BioAssays by Target

Select item 1080712.

In vitro inhibitory activity of compound against AGT (O6-alkylguanine-DNA alkyltransferase) at a concentration of 0.1 uM using breast cancer MCF cells, expressed as Fmol O6-MeG removed/mg of protein

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:3 Tested

AID:: 108071

Summary PubMed Citation Related BioAssays by Target

Select item 1080723.

In vitro inhibitory activity of compound against AGT (O6-alkylguanine-DNA alkyltransferase) at a concentration of 1 uM using breast cancer MCF-7 cells, expressed as Fmol O6-MeG removed/mg of protein

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:1 Tested

AID:: 108072

Summary PubMed Citation Related BioAssays by Target

Select item 1080734.

In vitro inhibitory activity of compound against AGT (O6-alkylguanine-DNA alkyltransferase) at a concentration of 10 uM using breast cancer MCF cells, expressed as Fmol O6-MeG removed/mg of protein

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:3 Tested

AID:: 108073

Summary PubMed Citation Related BioAssays by Target

Select item 1080745.

In vitro inhibitory activity of compound against AGT (O6-alkylguanine-DNA alkyltransferase) at a concentration of 50 uM using breast cancer MCF cells, expressed as Fmol O6-MeG removed/mg of protein

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:3 Tested

AID:: 108074

Summary PubMed Citation Related BioAssays by Target

Select item 1080756.

In vitro inhibitory activity of compound against AGT (O6-alkylguanine-DNA alkyltransferase) at a concentration of 50 uM using breast cancer MCF-7 cells, expressed as Fmol O6-MeG removed/mg of protein

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:1 Tested

AID:: 108075

Summary PubMed Citation Related BioAssays by Target

Select item 1080767.

In vitro inhibitory activity of compound against AGT (O6-alkylguanine-DNA alkyltransferase) using breast cancer MDA-MB-435 cells, expressed as Fmol O6-MeG removed/mg of protein

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:1 Tested

AID:: 108076

Summary PubMed Citation Related BioAssays by Target

Select item 1468228.

Tested for the effective dose required to produce 50 percent inactivation of O6-alkylguanine-DNA alkyltransferase in HT-29 cell

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:15 Active, 13 Activity ≤ 1 µM, 19 Tested

AID:: 146822

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 1468239.

Tested for the effective dose required to produce 50 percent inactivation of O6-alkylguanine-DNA alkyltransferase in HT-29 cell free extract

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:13 Active, 7 Activity ≤ 1 µM, 19 Tested

AID:: 146823

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 14682410.

Tested for the effective dose required to produce 50 percent inactivation of O6-alkylguanine-DNA alkyltransferase in HT-29 cell free extract; Inactive

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:1 Tested

AID:: 146824

Summary PubMed Citation Related BioAssays by Target

Select item 14682511.

Tested for the effective dose required to produce 50 percent inactivation of O6-alkylguanine-DNA alkyltransferase in HT-29 cell; Not Tested

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:1 Tested

AID:: 146825

Summary PubMed Citation Related BioAssays by Target

Select item 14746712.

O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity (Concentration of inactivator required to produce 50% reduction in ATPase activity)

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:15 Active, 13 Activity ≤ 1 µM, 16 Tested

AID:: 147467

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 14746813.

O6-Alkylguanine-DNA Alkyltransferase-Inactivating Activity in Raji cells (Concentration of inactivator required to produce 50% reduction in ATPase activity)

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:15 Active, 13 Activity ≤ 1 µM, 16 Tested

AID:: 147468

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 10650114.

In vitro inhibition of MGMT using cell free extracts from HeLa S3 cells

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:11 Active, 10 Activity ≤ 1 µM, 12 Tested

AID:: 106501

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 14747015.

In vitro inhibitory activity of compound against AGT (O6-alkylguanine-DNA alkyltransferase) at a concentration of 1 uM using breast cancer MCF cells, expressed as Fmol O6-MeG removed/mg of protein

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:3 Tested

AID:: 147470

Summary PubMed Citation Related BioAssays by Target

Select item 14747116.

In vitro inhibitory activity of compound against AGT (O6-alkylguanine-DNA alkyltransferase) at a concentration of 10 uM using breast cancer MCF-7 cells, expressed as Fmol O6-MeG removed/mg of protein

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:1 Tested

AID:: 147471

Summary PubMed Citation Related BioAssays by Target

Select item 14759617.

AGT-inactivating activity was determined by 50% inactivation in HT-29 cell free extract upon incubation for 30 min

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:14 Active, 12 Activity ≤ 1 µM, 22 Tested

AID:: 147596

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 14759718.

AGT-inactivating activity was determined by 50% inactivation in HT-29 cells upon incubation for 4 h

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:16 Active, 13 Activity ≤ 1 µM, 22 Tested

AID:: 147597

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 14759819.

In vitro inactivation of human O6-alkylguanine-DNA alkyltransferase in the absence of calf thymus DNA (ctDNA)

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested

AID:: 147598

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 14759920.

In vitro inactivation of human O6-alkylguanine-DNA alkyltransferase in the presence of calf thymus DNA (ctDNA)

Source:: ChEMBL

Protein Target:: Methylated-DNA--protein-cysteine methyltransferase

Assay data:7 Active, 5 Activity ≤ 1 µM, 7 Tested

AID:: 147599

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

RNAi Target, Active (7)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (34)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (23)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (35)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (10)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (86)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (14)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (86)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (13)
BioAssays deposited by other experimentalists

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