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Selectivity interaction (ITC) EUB0000731a MLLT3
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (DSF assay) EUB0000731a MLLT3
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (BioLayer Interferometry assay (BLI)) EUB0000731a MLLT3
Affinity Biochemical interaction (HTRF-based inhibition assay) EUB0000732a MLLT3
Affinity Biochemical interaction (HTRF-based inhibition assay) EUB0000731a MLLT3
Affinity Biochemical interaction (AlphaScreen assay) EUB0000283b MLLT3
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000732a MLLT3
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000731a MLLT3
Binding affinity to AF9 in human MOLM-13 cells assessed as thermal stabilization of protein at 55 degree celcius for 12 hrs by CETSA
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to MBP-tagged human recombinant AF9 (487 to 568 residues) incubated for 40 mins by measuring fluorescence polarization by microplate reader method
Assay data:13 Active, 13 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to AF9 in human MOLM-13 cells assessed as thermal stabilization of protein at 60 degree celcius at 1 uM for 12 hrs by CETSA
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Reverse ITC (compound as receptor). Domain start/stop: M1-D141
Thermal Shift Assay. Domain: start/stop M1-D141
Homogeneous Time Resolved Fluorescence (HTRF) assay. Domain start/stop: M1-D141
Inhibition of sfGFP-fused AF9 (unknown origin) transfected in human U2OS cells assessed as inhibition of YEATS-dependent AF9-chromatin association by measuring fluorescence recovery rate at 20 uM by FRAP assay (Rvb = 1.91 s)
Assay data:2 Tested
Binding affinity to AF9 YEATS domain (1 to 138 residues) (unknown origin) by isothermal titration calorimetry
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of AF9 YEATS domain (1 to 138 residues) (unknown origin) assessed as inhibition of probe-1 induced AF9 YEATS domain labelling incubated for 10 mins followed by UV-irradiation for 20 mins by Photo-cross linking based In-gel fluorescence scanning analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Stabilization of AF9 in human HeLa cells assessed as inhibition of high temperature-induced AF9 protein degradation at 20 uM incubated for 5 hrs by cellular thermal shift assay
Inhibition of human His-AF9 YEATS domain and biotinylated H3K9ac peptide interaction at 20 uM by AlphaScreen assay
Assay data:4 Active, 4 Tested
Inhibition of human His-AF9 YEATS domain and biotinylated H3K9ac peptide interaction by AlphaScreen assay
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
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