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Inhibition of COX-2 (unknown origin)-mediated TMPD oxidation using PGG2 as substrate at 100 uM incubated 15 mins prior to substrate addition measured after 36 secs by spectrophotometric analysis
Assay data:11 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human COX2 assessed as reduction in PGF2alpha production at 100 uM by ELISA
Assay data:4 Tested
Inhibition of human COX2 assessed as reduction in PGF2alpha production by ELISA
Assay data:3 Active, 2 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human COX2 expressed in baculovirus infected sf9 microsomes at 10 uM using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition by TMPD oxidation based assay relative to control
Assay data:2 Tested
Assay data:7 Tested
Inhibition of recombinant human COX2 assessed as decrease in PGE2 production at 10 uM using arachidonic acid as substrate preincubated for 15 mins prior to substrate addition for 5 mins relative to control
Assay data:6 Tested
Binding affinity to recombinant human COX2 at 10 uM after 5 mins by fluorescence assay relative to control
Assay data:1 Tested
Inhibition of recombinant human N-terminal His-tagged COX2 expressed in baculovirus infected Sf21 cells at 10 uM using arachidonic acid as substrate pretreated for 15 mins followed by substrate addition measured after 5 mins relative to control
Inhibition of COX2 in human Hs294 cells assessed as reduction in PGE2 production up to 20 uM by immunoblot analysis relative to control
Inhibition of COX2 in human A375 cells assessed as reduction in PGE2 production up to 20 uM by immunoblot analysis relative to control
Inhibition of recombinant human COX2 assessed as reduction in PGF2alpha at 10 uM incubated for 2 mins using arachidonic acid as substrate by ELISA relative to control
Assay data:24 Tested
Inhibition of human recombinant COX-2 mediated formation of 12-HHT from arachidonic acid assessed as remaining activity at 10 uM after 5 mins by HPLC analysis
Assay data:15 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
SummaryPubMed Citation
Inhibition of human COX-2 at 10 uM by ELISA
Assay data:8 Tested
Inhibition of human COX-2 at 10 uM by ELISA relative to licofelone
Inhibition of COX2-dependent PGE2 production in IL1B stimulated human A549 cells at 0.040 uM in presence of arachidonic acid
Inhibition of COX2-dependent PGE2 production in IL1B stimulated human A549 cells at 0.040 uM
Inhibition of COX2-dependent PGE2 production in IL1B stimulated human A549 cells
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of COX2 in microsomes at 100 uM
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