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Inhibition of human DMT1 expressed in HEK293T cells by measuring inhibition of radiolabeled 55Fe2+ uptake at 10 uM preincubated with compound for 5 mins followed by incubation with Fe2+ and radiolabeled 55Fe2+ for 15 mins at extracellular pH of 5.5 by scintillation counting analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human DMT1 expressed in Xenopus laevis oocytes assessed as reduction in radiolabeled 55Fe2+ uptake at 10 uM preincubated for 5 mins followed by incubation with Fe2+ and radiolabeled 55Fe2+ and measured after 10 mins by scintillation counting method relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human DMT1 expressed in HEK293T cells assessed as inhibition of radiolabeled 55Fe2+ uptake preincubated with compound for 5 mins followed by incubation with Fe2+ and radiolabeled 55Fe2+ for 15 mins at extracellular pH of 5.5 by scintillation counting analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human DMT1 expressed in HEK293 cells assessed as inhibition of radiolabeled 55Fe2+ uptake incubated for 1 hr by microplate scintillation counting analysis
Assay data:1 Active, 2 Tested
Inhibition of human DMT1 expressed in Xenopus oocytes assessed as inhibition of channel currents at -50 mV holding potential by two-electrode voltage clamp assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Competitive inhibition of human DMT1 expressed in HEK293T cells by measuring inhibition of radiolabeled-55Fe2+ uptake in presence of saturating iron concentration by Dixon plot analysis
Competitive inhibition of human DMT1 expressed in HEK293T cells by measuring inhibition of radiolabeled-55Fe2+ uptake by Dixon plot analysis
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Human DMT1 (SLC11 family of proton-coupled metal ion transporters)
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
Inhibition of human DMT1 at 10 uM after 20 mins by calcein quenching fluorescence assay relative to desferoxamine
Assay data:10 Tested
Inhibition of human DMT1 expressed in CHO cells assessed as effect on ionic current at 10 uM by whole-cell voltage clamp assay
Assay data:2 Tested
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