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NanoBRET assay (NTRK2, SGC Frankfurt)
Assay data:2 Tested
SummaryRelated BioAssays by Target
NTRK2 Invitrogen Lab (UK) kinase screen (BI)
Assay data:1 Tested
Inhibition of TRKB (unknown origin) using TK as substrate in presence of ATP incubated for 40 mins by HTRF KinEASE assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of TRKB (unknown origin) at 1 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of TRKB (unknown origin) by Ambit kinase assay
Assay data:3 Tested
Inhibition of TRKB (unknown origin) in presence of 25 uM ATP
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of TRKB (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of TrkB (unknown origin)
Activation of TrkB (unknown origin) relative to control
Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay))
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a NTRK2
Selectivity interaction (Enzymatic assay) EUB0000624a NTRK2
Selectivity interaction (Ambit kinome screening platform (Ambit phage-based competition binding assay)) EUB0000624a NTRK2
Affinity Biochemical interaction (Radiometric assay (10 M ATP, Reaction Biology)) EUB0000005b NTRK2
Affinity Biochemical interaction (LanthaScreenTM Eu) EUB0000640a NTRK2
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000156b NTRK2
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000005b NTRK2
Affinity Phenotypic Cellular interaction (Cell proliferation assay in TRK fusion?containing KM12 cells) EUB0000640a NTRK2
Inhibition of NTRK2 (TRKB) (unknown origin) at 0.1 uM relative to control
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