BioAssay by Target (List) for Gene (Select 4915) - PubChem BioAssay - NCBI

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Select item 19631181.

NanoBRET assay (NTRK2, SGC Frankfurt)

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:2 Tested

AID:: 1963118

Summary Related BioAssays by Target

Select item 19624342.

NTRK2 Invitrogen Lab (UK) kinase screen (BI)

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:1 Tested

AID:: 1962434

Summary Related BioAssays by Target

Select item 19622873.

NTRK2 Invitrogen Lab (UK) kinase screen (BI)

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:1 Tested

AID:: 1962287

Summary Related BioAssays by Target

Select item 19614744.

Inhibition of TRKB (unknown origin) using TK as substrate in presence of ATP incubated for 40 mins by HTRF KinEASE assay

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1961474

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19559075.

Inhibition of TRKB (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:1 Tested

AID:: 1955907

Summary PubMed Citation Related BioAssays by Target

Select item 19490166.

Inhibition of TRKB (unknown origin) by Ambit kinase assay

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:3 Tested

AID:: 1949016

Summary PubMed Citation Related BioAssays by Target

Select item 19431077.

Inhibition of TRKB (unknown origin) in presence of 25 uM ATP

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1943107

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19340748.

Inhibition of TRKB (unknown origin)

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1934074

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19223849.

Inhibition of TrkB (unknown origin)

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1922384

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192238210.

Activation of TrkB (unknown origin) relative to control

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:1 Tested

AID:: 1922382

Summary PubMed Citation Related BioAssays by Target

Select item 191548111.

Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay))

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1915481

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191381312.

Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a NTRK2

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913813

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191352613.

Selectivity interaction (Enzymatic assay) EUB0000624a NTRK2

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913526

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191352514.

Selectivity interaction (Ambit kinome screening platform (Ambit phage-based competition binding assay)) EUB0000624a NTRK2

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:1 Tested

AID:: 1913525

Summary Related BioAssays by Target

Select item 191319815.

Affinity Biochemical interaction (Radiometric assay (10 M ATP, Reaction Biology)) EUB0000005b NTRK2

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913198

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191309516.

Affinity Biochemical interaction (LanthaScreenTM Eu) EUB0000640a NTRK2

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913095

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191295217.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000156b NTRK2

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:1 Active, 1 Tested

AID:: 1912952

Summary Compounds, Active Related BioAssays by Target

Select item 191294318.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000005b NTRK2

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912943

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191268219.

Affinity Phenotypic Cellular interaction (Cell proliferation assay in TRK fusion?containing KM12 cells) EUB0000640a NTRK2

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912682

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 190057220.

Inhibition of NTRK2 (TRKB) (unknown origin) at 0.1 uM relative to control

Source:: ChEMBL

Protein Target:: BDNF/NT-3 growth factors receptor

Assay data:2 Tested

AID:: 1900572

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (3)
BioAssays with protein sequences specified as targets
RNAi Target, Active (9)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (164)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (29)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (127)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (159)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (400)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (45)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (356)
BioAssays extracted from the literature
NIH MLP (2)
BioAssays deposited by the NIH Molecular Libraries Program
Other (86)
BioAssays deposited by other experimentalists

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