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Selectivity interaction (KinomeScan (DiscoverX)) EUB0000710a TNNI3K
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of TNNI3K (unknown origin) at 10 uM
SummaryPubMed CitationRelated BioAssays by Target
TNNI3K DiscoveRx kinase panel
KinomeScan assay: inhibition of TNNI3K
Assay data:108 Tested
HH498(TNNILGY1) Takeda global kinase panel
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding affinity to full length human His-MBP-TNNI3K assessed as half life in presence of rhodamine green labeled GW805818X by fluorescence competitive binding assay
Binding affinity to full length human His-MBP-TNNI3K assessed as off-rate constant in presence of rhodamine green labeled GW805818X by fluorescence competitive binding assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human myc-TNNI3K expressed in HEK-MSR2 cells assessed as reduction in TNNI3K autophosphorylation preincubated for 30 mins followed by pervanadate addition and measured after 20 mins by DELFIA
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
Inhibition of TNNI3K (unknown origin)
Assay data:49 Active, 47 Activity ≤ 1 µM, 53 Tested
Inhibition of human TNNI3K assessed as percent of control at 2000 nM by KINOMEscan assay relative to control
Inhibition of DNA-tagged human TNNI3K assessed as percent of control at 50000 nM by qPCR analysis relative to control
Inhibition of human TNNI3K assessed as percent of control at 1000 nM by KINOMEscan assay relative to control
Inhibition of TNNI3K (unknown origin) using biotinylated CTnI as substrate by HTRF analysis
Inhibition of TNNI3K (unknown origin) assessed as residual activity at 1 uM using biotinylated CTnI as substrate by HTRF analysis relative to control
Assay data:35 Tested
Inhibition of human full length TNNI3K (M1 to S835 residues) expressed in bacterial expression system assessed as residual activity at 10 uM by kinome scan method relative to control
Binding affinity to wild-type human full length TNNI3K (M1 to S835 residues) expressed in bacterial expression system assessed as residual binding level at 10 uM by Kinomescan method relative to control
Inhibition of wild-type human full length TNNI3K (M1 to S835 residues) expressed in bacterial expression system at 1 uM by Kinomescan method relative to control
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