BioAssay by Target (List) for Gene (Select 5145) - PubChem BioAssay - NCBI

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Select item 19618161.

Compound was evaluated for inhibition of human PDE6A in an in vitro cell free assay measured by scintillation proximity assay

Source:: ChEMBL

Protein Target:: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

Assay data:2 Active, 1 Activity ≤ 1 µM, 68 Tested

AID:: 1961816

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19606932.

Inhibition of PDE6 (unknown origin) by 3H-cAMP scintillation proximity assay

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Tested

AID:: 1960693

Summary PubMed Citation Related BioAssays by Target

Select item 19244713.

Inhibition of PDE6 (unknown origin) assessed as inhibition constant

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Activity ≤ 1 µM, 1 Tested

AID:: 1924471

Summary Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19196244.

PDE5 Inhibition Assay from US Patent US10626113: "Phosphodiesterase inhibitors and uses thereof"

Source:: BindingDB

Protein Targets:: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; ...
Total:: 2

Assay data:14 Active, 4 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested

AID:: 1919624

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19146685.

Selectivity interaction (PDE panel (enzymatic activity assay)) EUB0000751a PDE6A

Source:: ChEMBL

Protein Target:: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914668

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19146166.

Selectivity interaction (PDE panel (enzymatic assay)) EUB0000744a PDE6A

Source:: ChEMBL

Protein Target:: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

Assay data:1 Tested

AID:: 1914616

Summary Related BioAssays by Target

Select item 18836877.

Inhibition of PDE6 (unknown origin)

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Active, 1 Tested

AID:: 1883687

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18725788.

Inhibition of PDE6 (unknown origin)

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1872578

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18660749.

Inhibition of PDE6 (unknown origin) using FAM-cGMP or FAM-cAMP as substrate incubated for 60 mins and measured by fluorescence polarization assay

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1866074

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 185926810.

Inhibition of cAMP-specific 3',5'-cyclic phosphodiesterase (unknown origin)

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 23

Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 1859268

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 181374111.

Inhibition of human PDE4 at 10 uM relative to control

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 23

Assay data:1 Tested

AID:: 1813741

Summary PubMed Citation Related BioAssays by Target

Select item 181211912.

Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP Assay

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 23

Assay data:8 Active, 8 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested

AID:: 1812119

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 180683913.

PDE Enzyme Assay from US Patent US11453673: "Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors"

Source:: BindingDB

Protein Targets:: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; ...
Total:: 2

Assay data:2 Active, 16 Tested

AID:: 1806839

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Target

Select item 180668914.

Enzyme Assays from US Patent US11401274: "[1,2,4]Triazolo derivatives as PDE1 inhibitors for the treatment of diabetes"

Source:: BindingDB

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 7

Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested

AID:: 1806689

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180616215.

PDE Enzyme Assays Using [3H]cGMP as Substrate from US Patent US11180503: "[1,2,4]Triazolo[4,3-A]pyrazin-6(5H)-one derivatives"

Source:: BindingDB

Protein Targets:: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; ...
Total:: 2

Assay data:8 Active, 2 Activity ≤ 1 µM, 13 Tested

AID:: 1806162

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 180521516.

Inhibition Assay from US Patent US10899756: "Phosphodiesterase inhibitors and uses thereof"

Source:: BindingDB

Protein Targets:: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; ...
Total:: 2

Assay data:23 Active, 7 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 23 Tested

AID:: 1805215

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179144117.

PDE6 CEREP ligand profiling

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Tested

AID:: 1791441

Summary Related BioAssays by Target

Select item 179122418.

Biochemical assay (PDE6A)

Source:: ChEMBL

Protein Target:: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

Assay data:1 Activity ≤ 1 µM, 2 Tested

AID:: 1791224

Summary Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 178701019.

hPDE6AB PDE scan

Source:: ChEMBL

Protein Target:: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

Assay data:1 Tested

AID:: 1787010

Summary Related BioAssays by Target

Select item 177680420.

Inhibition of human PDE6

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:2 Tested

AID:: 1776804

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (32)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (5)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (27)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (51)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (64)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (59)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (17)
BioAssays deposited by other experimentalists

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