BioAssay by Target (List) for Gene (Select 5146) - PubChem BioAssay - NCBI

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Select item 19606931.

Inhibition of PDE6 (unknown origin) by 3H-cAMP scintillation proximity assay

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Tested

AID:: 1960693

Summary PubMed Citation Related BioAssays by Target

Select item 19244712.

Inhibition of PDE6 (unknown origin) assessed as inhibition constant

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Activity ≤ 1 µM, 1 Tested

AID:: 1924471

Summary Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18836873.

Inhibition of PDE6 (unknown origin)

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Active, 1 Tested

AID:: 1883687

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18725784.

Inhibition of PDE6 (unknown origin)

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1872578

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18660745.

Inhibition of PDE6 (unknown origin) using FAM-cGMP or FAM-cAMP as substrate incubated for 60 mins and measured by fluorescence polarization assay

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1866074

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18592686.

Inhibition of cAMP-specific 3',5'-cyclic phosphodiesterase (unknown origin)

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 23

Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 1859268

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18137417.

Inhibition of human PDE4 at 10 uM relative to control

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 23

Assay data:1 Tested

AID:: 1813741

Summary PubMed Citation Related BioAssays by Target

Select item 18121198.

Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP Assay

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 23

Assay data:8 Active, 8 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested

AID:: 1812119

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18018009.

In Vitro Enzyme Assay from US Patent US9173884: "Inhibitors of phosphodiesterase 11 (PDE11)"

Source:: BindingDB

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; ...
Total:: 11

Assay data:21 Active, 13 Activity ≤ 1 µM, 25 Tested

AID:: 1801800

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179970610.

In Vitro Enzyme Assay from Article 10.1016/j.chembiol.2011.12.010: "Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen."

Source:: BindingDB

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; ...
Total:: 10

Assay data:9 Active, 5 Activity ≤ 1 µM, 9 Tested

AID:: 1799706

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 179144111.

PDE6 CEREP ligand profiling

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Tested

AID:: 1791441

Summary Related BioAssays by Target

Select item 178303412.

Inhibition of PDE6C (unknown origin) at 10 uM relative to control

Source:: ChEMBL

Protein Target:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

Assay data:1 Tested

AID:: 1783034

Summary PubMed Citation Related BioAssays by Target

Select item 177680413.

Inhibition of human PDE6

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:2 Tested

AID:: 1776804

Summary PubMed Citation Related BioAssays by Target

Select item 176056914.

Inhibition of recombinant human PDE6C assessed as hydrolysis of [3H]-cAMP measured after 30 mins by Scintillation proximity assay

Source:: ChEMBL

Protein Target:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

Assay data:1 Tested

AID:: 1760569

Summary PubMed Citation Related BioAssays by Target

Select item 175032015.

Inhibition of recombinant full length GST-tagged PDE6C (unknown origin) expressed in baculovirus infected Sf9 insect cells at 15 uM using TAMRA-cGMP as substrate incubated for 1.5 hrs by IMAP-FP assay relative to control

Source:: ChEMBL

Protein Target:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

Assay data:1 Tested

AID:: 1750320

Summary PubMed Citation Related BioAssays by Target

Select item 175030716.

Inhibition of recombinant full length GST-tagged PDE6C (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as substrate incubated for 1.5 hrs by IMAP-FP assay

Source:: ChEMBL

Protein Target:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

Assay data:5 Tested

AID:: 1750307

Summary PubMed Citation Related BioAssays by Target

Select item 172500117.

Inhibition of recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected Sf9 cells at 10 uM by radioligand assay relative to control

Source:: ChEMBL

Protein Target:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

Assay data:1 Tested

AID:: 1725001

Summary PubMed Citation Related BioAssays by Target

Select item 172355918.

Inhibition of human PDE6C (2-854 residues) expressed in Sf9 cells incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation counting method

Source:: ChEMBL

Protein Target:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

Assay data:5 Tested

AID:: 1723559

Summary PubMed Citation Related BioAssays by Target

Select item 168535719.

Inhibition of PDE (unknown origin)

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 23

Assay data:1 Tested

AID:: 1685357

Summary PubMed Citation Related BioAssays by Target

Select item 165941420.

Inhibition of PDE6 (unknown origin)

Source:: ChEMBL

Protein Targets:: Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; ...
Total:: 6

Assay data:1 Tested

AID:: 1659414

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (38)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (5)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (32)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (59)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (87)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (86)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (13)
BioAssays deposited by other experimentalists

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