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ENPP1 Inhibition Assay from US Patent US20240034727: "IMIDAZOLE COMPOUNDS AS INHIBITORS OF ENPP1"
Assay data:23 Active, 12 Activity ≤ 1 µM, 35 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of ENPP1 (unknown origin)
Assay data:19 Active, 17 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ENPP1 (unknown origin) at 10 uM relative to control
Assay data:29 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ENPP1 Hydrolysis of 2′,3′-cGAMP from US Patent US11780849: "Imino sulfanone inhibitors of ENPP1"
Assay data:205 Active, 182 Activity ≤ 1 µM, 239 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:72 Active, 90 Activity ≤ 1 µM, 90 Tested
ENPP1 Activity Assay (32P cGAMP)) from US Patent US20230277570: "ENPP1 Inhibitors and Their Use for the Treatment of Cancer"
Assay data:6 Active, 4 Activity ≤ 1 µM, 6 Tested
ENPP1 Activity Assay (TMP-pNP) from US Patent US20230277570: "ENPP1 Inhibitors and Their Use for the Treatment of Cancer"
Assay data:31 Active, 26 Activity ≤ 1 µM, 34 Tested
ENPP1 Activity Assay from US Patent US11701371: "ENPP1 inhibitors and their use for the treatment of cancer"
ENPP1 Assay from US Patent US11591313: "Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and methods of use thereof"
Assay data:39 Active, 3 Activity ≤ 1 nM, 39 Activity ≤ 1 µM, 39 Tested
Inhibition of recombinant human soluble NPP1 expressed in Sf9 insect cells using ATP as substrate measured after 30 mins by capillary electrophoresis
Assay data:1 Tested
ENPP1 Assay (ATP) from US Patent US11142524: "Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics"
Assay data:6 Active, 5 Activity ≤ 1 µM, 8 Tested
ENPP1 Assay (TMP) from US Patent US11142524: "Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics"
Assay data:7 Active, 3 Activity ≤ 1 µM, 14 Tested
ENPP1 Inhibition Assay from US Patent US11142524: "Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics"
Assay data:30 Active, 15 Activity ≤ 1 µM, 39 Tested
Inhibition Assay from US Patent US10689376: "Substituted-3H-imidazo [4,5-c] pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics"
ENPP1 Enzyme Assay with eGAMP Substrate from US Patent US20230159469: "NOVEL PHTHALAZINE DERIVATIVE HAVING ECTONUCLOEOTIDE PYROPHOSPHATASE/PHOSPHODIESTE RASE INHIBITORY ACTIVITY, AND USE THEREOF"
Assay data:78 Active, 41 Activity ≤ 1 µM, 127 Tested
Non-competitive inhibition of human NPP1 transfected in COS7 cells at 0.5 to 1.5 uM using pNP-TMP as substrate incubated for 35 mins by Lineweaver-Burk plot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human NPP1 transfected in COS7 cells at 100 uM using pNP-TMP as substrate incubated for 35 mins relative to control
Assay data:3 Tested
Inhibition of human NPP1 transfected in COS7 cells using pNP-TMP as substrate incubated for 35 mins
Assay data:9 Active, 1 Activity ≤ 1 µM, 11 Tested
Inhibition of NPP1 (unknown origin) transfected in COS7 cells using pNP-TMP as substrate incubated for 35 mins by spectrophotometric method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Stability in presence of ENPP1 ( unknown origin) assessed as half life by HPLC analysis
Assay data:2 Tested
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