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Inhibition of KDM4D (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human KDM4D measured by AlphaLISA assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of KDM4D (unknown origin) measured by AlphaLisa-based screening assay
Inhibition of human KDM4D (1 to 378 residues) catalytic domain measured formaldehyde dehydrogenase (FDH)-coupled fluorescence assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of KDM4D (unknown origin)
Inhibition of His-tagged human KDM4D (1 to 350 residues) measured by ELISA assay
Inhibition of KDM4D (unknown origin) using H3K9me3 as substrate and measured by LANCE TR-FRET assay
Inhibition of KDM4D (unknown origin) measured by RapidFire mass spectrometry (RFMS)
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of GST-tagged recombinant KDM4D (unknown origin) expressed in Escherichia coli BL21 incubated for 30 mins by fluorescence based assay
Inhibition of human N-terminal His6-tagged KDM4D (M1 to G373 residues) expressed in Escherichia coli using H3K9(Me3) as substrate preincubated for 15 mins followed by substrate addition and measured after 8 mins by Alphascreen assay
Assay data:13 Tested
Binding affinity to KDM4D (unknown origin) by differential scanning fluorimetry
Inhibition of KDM4D (unknown origin) by Succinate-Glo assay
Binding affinity to human KDM4D expressed in Escherichia coli BL21(DE3) assessed as positive thermal shift in melting temperature measured for 60 mins by differential scanning fluorimetry assay
Inhibition of KDM4D in human HCT-116 cells assessed as reduction in c-myc protein expression incubated for 48 hrs measured by Western blot analysis
Inhibition of KDM4D in human HCT-116 cells assessed as reduction in beta-catenin protein expression incubated for 48 hrs measured by Western blot analysis
Inhibition of KDM4D in human HCT-116 cells assessed as reduction in Gli1 protein expression incubated for 48 hrs measured by Western blot analysis
Inhibition of GST-tagged KDM4D (unknown origin) expressed in Escherichia coli DH5alpha assessed as histone demethylation activity using H3K9me3 as substrate incubated for 4 hrs in presence of FLAG-histone H3 measured by Western blot analysis
Mixed inhibition of human KDM4D expressed in Escherichia coli BL21(DE3) using H3(1-21)K9me3 peptide and varying concentrations of 2-OG as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by Michaelis-Menten plot based analysis
Binding affinity to human KDM4D expressed in Escherichia coli BL21(DE3) assessed as negative thermal shift in melting temperature measured for 60 mins by differential scanning fluorimetry assay
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