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PRKCA Invitrogen Lab (UK) kinase screen (BI)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of PKCa (unknown origin) at 10 uM by biochemical hotspot kinase assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PKC (unknown origin) using acetylated myelin basic protein (4 to 14 residues) as substrate incubated for [gamma-32P]-ATP incubated for 5 mins by scintillation counter analysis
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation at 100 nM incubated for 15 mins by immunoblotting analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation at 0.1 to 10 uM incubated for 15 mins by immunoblotting analysis
Assay data:3 Tested
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation at 10 uM pretreated with PMA for 24 hrs followed by compound addition and measured after 15 mins by immunoblotting analysis
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation incubated for 15 mins by immunoblotting analysis
Assay data:2 Tested
Inhibition of PKC (unknown origin)
Inhibition of PKCalpha (unknown origin) at 1000 nM relative to control
Inhibition of PKCa (unknown origin) at 25 nM relative to control
Assay data:6 Tested
Inhibition of Protein kinase C (unknown origin)
Assay data:3 Active, 1 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human PKC
Inhibition of [3H]-PDBu binding to PKCalpha C1A domain (unknown origin) by competitive binding assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000749a PRKCA
Selectivity interaction (Kinase panel (University of Dundee)) EUB0000169b PRKCA
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000704a PRKCA
Affinity Biochemical interaction (Filter-binding assays) EUB0000154b PRKCA
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (Antiproliferation against diverse cancer cell lines (HCT116; PC3-prostate cacinoma cell and U87MG glioblastoma cells)) EUB0000154b PRKCA
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