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MAP2K7 SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of human recombinant full-length MEK7 using JNK1 as substrate incubated for 30 mins followed by ATP addition measured after 1 hr by ADP Glo luminescent assay
Assay data:30 Active, 19 Activity ≤ 1 µM, 33 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Thermal Shift Assay. Domain: start/stop: S60-R405
Assay data:27 Tested
Binding affinity to N-terminal 6XHis-tagged recombinant MKK7 (117 to 423 residues) (unknown origin) assessed as protein labelling at 2 uM measured for 10 mins by LC/MS analysis relative to control
Assay data:18 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of N-terminal 6XHis-tagged recombinant MKK7 (117 to 423 residues) in human U2OS assessed as reduction in c-Jun phosphorylation level incubated for 80 mins by Western blot analysis
Assay data:5 Active, 5 Activity ≤ 1 µM, 10 Tested
Inhibition of N-terminal 6XHis-tagged recombinant MKK7 (117 to 423 residues) (unknown origin) expressed in Escherichia coli BL21-DE3 preincubated for 2 hrs in presence of ATP measured after 17 hrs
Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of N-terminal 6XHis-tagged recombinant MKK7 (117 to 423 residues) in human U2OS cells assessed as reduction in JNK phosphorylation level at 13.8 uM incubated for 2 hrs by ICW detection method relative to control
Assay data:12 Tested
Binding affinity to MKK7 (unknown origin) assessed as percent of control at 100 nM by Kinomescan method relative to control
Assay data:30 Tested
MKK7 DiscoveRx kinase panel
Inhibition of MKK7 (unknown origin) at 1 uM
Kinase Assay from US Patent US10844038: "1,2-dithiolane compounds useful in neuroprotection, autoimmune and cancer diseases and conditions"
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
JAK Enzyme Assay from Article 10.1021/acschembio.6b00677: "Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition."
Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
KinomeScan assay: inhibition of MKK7
Assay data:108 Tested
MAP2K7(M2K7CGRI) Takeda global kinase panel
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
MKK7beta(h) Eurofins kinase panel
MKK7?beta(h) Upstate kinase activity assay
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