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Inhibition of BACE2 in mouse MIN6 cells expressing TMEM27 assessed as reduction in TMEM27 secretion incubated for 24 hrs by MSD electrochemiluminescence assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
In Vitro Enzymatic BACE1 and BACE2 FRET (Fluorescence Resonance Energy Transfer) Assays from US Patent US10947223: "Substituted oxazines as beta-secretase inhibitors"
Assay data:18 Active, 17 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
ELISA Assay from US Patent US9067924: "1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors"
Assay data:14 Active, 13 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of BACE2 in mouse MIN6 cells expressing wild type TMEM27 assessed as reduction in TMEM27 secretion by MSD electrochemiluminescence assay
Inhibition of BACE2 in mouse B16-F1 cells assessed as increase in intracellular PMEL17 Mbeta accumulation measured after 4 days by Western blot analysis
Inhibition of BACE2 in mouse follicular epithelial melanosomes assessed as alteration in melanosome morphology at 135 mg/kg bid by transmission electron microscopic analysis
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of BACE2 in mouse follicular epithelial melanosomes assessed as alteration in melanosome morphology at 21.5 mg/kg bid by transmission electron microscopic analysis
Inhibition of BACE2 in mouse follicular epithelial melanosomes assessed as reduction in number of melanosome at 135 mg/kg bid by transmission electron microscopic analysis
Inhibition of BACE2 in mouse follicular epithelial melanosomes assessed as reduction in number of melanosome at 21.5 mg/kg bid by transmission electron microscopic analysis
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
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