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Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 90 mins by fluorescence assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of 20S proteasome in human MelJuSo UbG76V-YFP cells assessed as accumulation of UbG76V-YFP protein at 0.1 uM after 6 hrs by immunoblot method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of 20S proteasome in human MelJuSo UbG76V-YFP cells assessed as accumulation of K48-linked poly-ubiquitinated proteins at 0.1 uM after 6 hrs by immunoblot method
Inhibition of erythrocyte 20S proteasome (unknown origin) assessed as inhibition of chymotrypsin activity at 10 uM after 15 mins using Suc-LLVY-AMC substrate by fluorescence assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of erythrocyte 20S proteasome (unknown origin) assessed as inhibition of chymotrypsin activity at 50 uM after 15 mins using Suc-LLVY-AMC substrate by fluorescence assay
Inhibition of erythrocyte 20S proteasome (unknown origin) assessed as inhibition of chymotrypsin activity after 15 mins using Suc-LLVY-AMC substrate by fluorescence assay
Inhibition of 20S proteasome in human HeLa cells expressing GFP-tagged ubiquitin G76V mutant at 26 nM after 16 hrs by fluorescence assay
Inhibition of 20S proteasome in human HeLa cells expressing GFP-tagged ubiquitin G76V mutant at 23 uM after 16 hrs by fluorescence assay
Assay data:1 Active, 2 Tested
Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate assessed as decrease in enzyme velocity
Assay data:2 Tested
Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrate
Assay data:17 Active, 16 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
SummaryPubMed Citation
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Summary
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
siRNA Circadian Assay
Assay data:527 Active, 33364 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
Inhibition of chymotrypsin-like of human 20S proteasome using chromophoric Suc-LLVY-AMC as substrate after 60 mins by fluorescence assay
Assay data:5 Active, 2 Activity ≤ 1 µM, 5 Tested
Inhibition of 26S proteosome in human Hep3B cells grown under in normoxic condition for 4 hrs assessed as downregulation of HIF1alpha level at 10 uM added together with cycloheximide and measured after up 45 mins post dose by Western blot analysis
SummaryPubMed CitationRelated BioAssays by Target
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