BioAssay by Target (List) for Gene (Select 57396) - PubChem BioAssay - NCBI

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Select item 19488721.

Inhibition of CLK4 (unknown origin)

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1948872

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19476812.

Inhibition of recombinant human CLK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:45 Active, 40 Activity ≤ 1 µM, 56 Tested

AID:: 1947681

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19340023.

Inhibition of CLK4 (unknown origin)

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1934002

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19339944.

Inhibition of human CLK4

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:16 Active, 16 Activity ≤ 1 µM, 16 Tested

AID:: 1933994

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19339935.

Inhibition of human CLK4 at 12 degree celcius

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:1 Active, 1 Tested

AID:: 1933993

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 19339896.

Inhibition of human CLK4 administered orally

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1933989

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19325857.

Inhibition of CLK1/2/4 (unknown origin) relative to control

Source:: ChEMBL

Protein Targets:: Dual specificity protein kinase CLK1; ...
Total:: 3

Assay data:1 Tested

AID:: 1932585

Summary PubMed Citation Related BioAssays by Target

Select item 19322678.

Inhibition of CLK4 (unknown origin)

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1932267

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19150429.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000348aPTSA CLK4

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:1 Tested

AID:: 1915042

Summary Related BioAssays by Target

Select item 191503110.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000347a CLK4

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:1 Tested

AID:: 1915031

Summary Related BioAssays by Target

Select item 191424311.

Selectivity interaction (ScanMAX (DiscoverX)) EUB0000298b CLK4

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914243

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191411912.

Selectivity interaction (SelectScreen (Invitrogen)) EUB0000715a CLK4

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914119

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191394513.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000702a CLK4

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:1 Tested

AID:: 1913945

Summary Related BioAssays by Target

Select item 191320314.

Affinity Biochemical interaction (NanoBRET assay (in HEK293T cells)) EUB0000009b CLK4

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:1 Tested

AID:: 1913203

Summary Related BioAssays by Target

Select item 191296215.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000724a CLK4

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912962

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191294816.

Affinity On-target Cellular interaction (MTT assay (cellular toxicity in MCF-7, MCF-10a and MDA-MB-231 cells, 24h)) EUB0000009b CLK4

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:1 Tested

AID:: 1912948

Summary Related BioAssays by Target

Select item 191291317.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000705a CLK4

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:1 Tested

AID:: 1912913

Summary Related BioAssays by Target

Select item 191289918.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000321b CLK4

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:1 Activity ≤ 1 µM, 1 Tested

AID:: 1912899

Summary Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191274019.

Affinity Phenotypic Cellular interaction (Changed alternative splicing pattern determined by mRNAseq) EUB0000321b CLK4

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912740

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 190468920.

Inhibition of CLK4 (unknown origin)

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK4

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1904689

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (16)
BioAssays with protein sequences specified as targets
RNAi Target, Active (8)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Chemical Probes (2)
BioAssays with compounds reported as validated chemical probes

Active Compounds (93)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (6)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (79)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (3)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (94)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (243)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (44)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (14)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (194)
BioAssays extracted from the literature
NIH MLP (15)
BioAssays deposited by the NIH Molecular Libraries Program
Other (77)
BioAssays deposited by other experimentalists

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