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Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
SummaryPubMed Citation
Inhibition of PDGF-BB-stimulated Rac1 activity assessed as blockade of Rac1-Tiam1 interaction in human aortic smooth muscle cells at 50 uM by SDS-PAGE based chemiluminescence
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Rac1 binding to Pak1 in human aortic smooth muscle cells at 50 uM by SDS-PAGE based chemiluminescence
Assay data:3 Active, 3 Tested
Inhibition of Rac1 binding to Pak1 in human aortic smooth muscle cells at 100 uM by SDS-PAGE based chemiluminescence
Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP at 50 uM after 40 mins by nucleotide binding competition assay
Assay data:23 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assay
Assay data:3 Active, 11 Tested
Inhibition of Rac1b GTPase activity assessed as incorporation of BODIPY-GTP at 50 uM after 40 mins by nucleotide binding competition assay
Inhibition of Rac1b GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assay
Assay data:5 Active, 11 Tested
Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer
Assay data:5 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer
Assay data:11 Active, 26 Tested
Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer
Assay data:23 Active, 25 Tested
Inhibition of p38sigma MAPK assessed as residual enzyme activity at 10 uM
Assay data:1 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of ratio of Rac1GTP/Rac1 levels at 25 uM after 4 hrs by pull-down assay
Assay data:4 Active, 5 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Inhibition of Rac1 activation
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Summary
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Inhibition of Rac1-mediated WAVE-2/Arp2/3 expression in human MDA-MB-231 cells at 25 to 50 uM after 24 mins by Western blotting analysis
Assay data:1 Active, 1 Tested
Inhibition of Rac1-mediated WAVE-2/Arp2/3 expression in human MDA-MB-231 cells after 24 mins by Western blotting analysis
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