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Inverse agonist activity at human GAL4-fused RORbeta LBD transfected in 293T cell measured after 24 hrs by dual luciferase assay
Assay data:6 Tested
SummaryRelated BioAssays by Target
Inhibition of human GAL4-fused RORbeta LBD transfected in HEK293T cell measured for 16 to 20 hrs by by dual-glo luciferase assay
Assay data:1 Tested
Inverse agonist activity at 6His-tagged RORB LBD (unknown origin) expressed in Escherichia coli assessed as inhibition of biotinylated SRC1-2 derived CPSSHSSLTERHKILHRLLQEGSPS-NH2 containing LXXLL coactivator peptide incubated for 3 hrs by TR-FRET assay
Inhibition of RORbeta (unknown origin) assessed as fold change
Inhibition of GAL4 DNA-binding domain fused full length human RORbeta (201 to 459 residues) expressed in HEK293T cells incubated for 16 to 20 hrs by one hybrid reporter assay
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to RORbeta (unknown origin)
Receptor Competition Binding Assay from US Patent US11008336: "Compounds useful for inhibiting RORγt"
Assay data:8 Active, 7 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biological Assay from US Patent US9598431: "Compounds useful for inhibiting ROR-gamma-t"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
ThermoFluor Binding Assay (RORB)
Assay data:2 Tested
Agonist activity at RORbeta (unknown origin)
Agonist activity at human RORB assessed as recruitment of PGC1alpha (130 to 154) coactivator peptide by TR-FRET assay
Inverse agonist activity at Gal4-fused RORbeta (unknown origin)
Inverse agonist activity at ROR-beta (unknown origin) expressed in HEK293 cells by Gal4-luciferase reporter assay
Inverse agonist activity at ROR-beta (unknown origin) expressed in Jurkat cells by gal4 reporter assay
Inhibition of RORbeta (unknown origin)
Inhibition of GAL4-fused RORbeta (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at Gal4-fused RORbeta (unknown origin)
Assay data:2 Active, 2 Tested
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