BioAssay by Target (List) for Gene (Select 6310) - PubChem BioAssay - NCBI

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Select item 19198181.

Autotaxin (ATX) Enzymatic Activity Inhibition Assay from US Patent US20230312582: "Salts Of Nitrogen-Containing Heterocyclic Compound, And Solid Forms Of Salts, Pharmaceutical Composition And Use Thereof"

Source:: BindingDB

Protein Targets:: Ataxin-1; ...
Total:: 1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1919818

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 19195012.

Human ATX Enzyme Inhibition Assay from US Patent US11673888: "Bicyclic compounds as ATX inhibitors"

Source:: BindingDB

Protein Targets:: Ataxin-1; ...
Total:: 1

Assay data:17 Active, 3 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested

AID:: 1919501

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 19193243.

Bioactivity Assay from US Patent US11591342: "Heterocyclic compound, application thereof and pharmaceutical composition comprising same"

Source:: BindingDB

Protein Targets:: Ataxin-1; ...
Total:: 1

Assay data:45 Active, 44 Activity ≤ 1 µM, 46 Tested

AID:: 1919324

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 18069644.

Biochemical ATX Assa from US Patent US11485727: "N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators"

Source:: BindingDB

Protein Targets:: Ataxin-1; ...
Total:: 1

Assay data:35 Active, 35 Activity ≤ 1 µM, 35 Tested

AID:: 1806964

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 18065875.

Human ATX Enzyme Inhibition Assay from US Patent US11352330: "Phenoxymethyl derivatives"

Source:: BindingDB

Protein Targets:: Ataxin-1; ...
Total:: 1

Assay data:204 Active, 9 Activity ≤ 1 nM, 195 Activity ≤ 1 µM, 210 Tested

AID:: 1806587

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 18059016.

Inhibition of ATX by Benzene Sulfonamide Series from US Patent US11124490: "Autotaxin inhibitors"

Source:: BindingDB

Protein Targets:: Ataxin-1; ...
Total:: 1

Assay data:14 Active, 23 Activity ≤ 1 µM, 23 Tested

AID:: 1805901

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 18058607.

Enzyme Inhibition Assay from US Patent US11098048: "Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors"

Source:: BindingDB

Protein Targets:: Ataxin-1; ...
Total:: 1

Assay data:64 Active, 64 Activity ≤ 1 µM, 64 Tested

AID:: 1805860

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 18057818.

Human ATX Enzyme Inhibition Assay from US Patent US11059794: "Heterocyclic compounds useful as dual ATX/CA inhibitors"

Source:: BindingDB

Protein Targets:: Ataxin-1; ...
Total:: 1

Assay data:70 Active, 11 Activity ≤ 1 nM, 70 Activity ≤ 1 µM, 70 Tested

AID:: 1805781

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor

Select item 18052469.

Enzyme Inhibition Assay from US Patent US10913745: "Octahydro-pyrrolo[3,4-c]-pyrrole derivatives and analogs thereof as autotaxin inhibitors"

Source:: BindingDB

Protein Targets:: Ataxin-1; ...
Total:: 1

Assay data:47 Active, 5 Activity ≤ 1 nM, 43 Activity ≤ 1 µM, 47 Tested

AID:: 1805246

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 180510310.

ATX Inhibition from US Patent US10865195: "Pet imaging agents"

Source:: BindingDB

Protein Targets:: Ataxin-1; ...
Total:: 1

Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested

AID:: 1805103

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 180508011.

Enzyme Inhibition Assay from US Patent US10849881: "Octahydro-cyclobuta[1,2-c;3,4-c′]dipyrrol-2-yl"

Source:: BindingDB

Protein Targets:: Ataxin-1; ...
Total:: 1

Assay data:115 Active, 2 Activity ≤ 1 nM, 110 Activity ≤ 1 µM, 116 Tested

AID:: 1805080

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 180491012.

Human Atx Enzyme Inhibition Assay from US Patent US10800786: "Bicyclic compounds as ATX inhibitors"

Source:: BindingDB

Protein Targets:: Ataxin-1; ...
Total:: 1

Assay data:32 Active, 3 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 32 Tested

AID:: 1804910

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 180484013.

Enzyme Inhibition Assay from US Patent US10787459: "Bicyclic compounds as ATX inhibitors"

Source:: BindingDB

Protein Targets:: Ataxin-1; ...
Total:: 1

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1804840

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 180468614.

Enzyme Inhibition Assay from US Patent US10738053: "Bicyclic compounds as dual ATX/CA inhibitors"

Source:: BindingDB

Protein Targets:: Ataxin-1; ...
Total:: 1

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1804686

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor

Select item 180448915.

Human ATX Enzyme Inhibition Assay from US Patent US10669285: "Condensed [1,4] diazepine compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors"

Source:: BindingDB

Protein Targets:: Ataxin-1; ...
Total:: 1

Assay data:43 Active, 42 Activity ≤ 1 µM, 43 Tested

AID:: 1804489

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 180448216.

Human ATX Enzyme Inhibition Assay from US Patent US10669268: "Bicyclic derivatives"

Source:: BindingDB

Protein Targets:: Ataxin-1; ...
Total:: 1

Assay data:304 Active, 2 Activity ≤ 1 nM, 274 Activity ≤ 1 µM, 306 Tested

AID:: 1804482

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 179717017.

Biological Assay from US Patent US9763957: "Autotaxin inhibitors"

Source:: BindingDB

Protein Targets:: Ataxin-1; ...
Total:: 1

Assay data:201 Active, 194 Activity ≤ 1 µM, 201 Tested

AID:: 1797170

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 150858818.

RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:790 Active, 18119 Tested

AID:: 1508588

Select item 122483019.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout

Source:: Iain Fraser

Assay data:2853 Active, 18113 Tested

AID:: 1224830

Summary Related BioAssays by Same Project

Select item 115958420.

A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:2442 Active, 18052 Tested

AID:: 1159584

Summary PubMed Citation

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Target

RNAi Target, Active (5)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (17)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (7)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (17)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (17)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (17)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (17)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (12)
BioAssays deposited by other experimentalists

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