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Inhibition of human IBAT
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to ASBT (unknown origin) assessed as inhibition constant
Assay data:2 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Pharmaceutical Effect Mean Inhibitory Effect from US Patent US10487111: "IBAT inhibitors for the treatment of liver diseases"
Assay data:12 Active, 11 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US9040518: "Chemical compounds"
Assay data:69 Active, 1 Activity ≤ 1 nM, 54 Activity ≤ 1 µM, 70 Tested
Pharmaceutical Effect Mean Inhibitory Effect from US Patent US10093697: "IBAT inhibitors for the treatment of liver diseases"
Assay data:11 Active, 10 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
Inhibition of human ASBT-mediated [3H]-TCA uptake expressed in human HepG2 cells at 2 uM
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human ASBT
Assay data:1 Tested
Inhibition of ASBT (unknown origin) at 1 to 10 uM
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of human IBAT expressed in COS cells assessed as reduction in [3H]taurocholic acid uptake
Assay data:3 Tested
Inhibition of human IBAT expressed in CHO cells assessed as reduction in [3H]taurocholic acid uptake incubated for 30 to 60 mins by scintillation counting method
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Induction of human NTCP receptor inhibition-mediated autophagy in HBV-infected human HepG2.2.15 cells assessed as MDC positive cells at 20 uM after 24 hrs by transmission electron microscopy (Rvb = 0.60%)
Induction of human NTCP receptor inhibition-mediated autophagy in HBV-infected human HepG2.2.15 cells assessed as MDC positive cells at 20 uM after 12 hrs by transmission electron microscopy (Rvb = 0.60%)
Induction of human NTCP receptor inhibition-mediated autophagy in HBV-infected human HepG2.2.15 cells assessed as increase in Beclin- 1 level after 9 days by Western blot analysis
Assay data:1 Active, 1 Tested
Induction of human NTCP receptor inhibition-mediated autophagy in HBV-infected human HepG2.2.15 cells assessed as decrease in p62 level at 20 uM after 24 hrs by Western blot analysis
Induction of human NTCP receptor inhibition-mediated autophagy in HBV-infected human HepG2.2.15 cells assessed as increase in LC3-2 level at 20 uM after 24 hrs by Western blot analysis
Induction of human NTCP receptor inhibition-mediated autophagy in HBV-infected human HepG2.2.15 cells assessed as GFP-LC3 localization at 20 uM by transmission electron microscopy
Induction of human NTCP receptor inhibition-mediated autophagy in HBV-infected human HepG2.2.15 cells assessed as GFP-LC3 localization at 20 uM after 24 hrs by transmission electron microscopy
Induction of human NTCP receptor inhibition-mediated autophagy in HBV-infected human HepG2.2.15 cells assessed as appearance of autophagosome and extensive cytoplasm vacuolization at 20 uM after 24 hrs by transmission electron microscopy
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