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Binding Competition Assay with Human NK-3 Receptor from US Patent US11731974: "N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists"
Assay data:47 Active, 47 Activity ≤ 1 µM, 47 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Tachykinin NK3 Eurofins-Panlabs radioligand binding assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
NK3 (h) CEREP panel
Displacement of [3H]SR 142801 from human recombinant NK3 receptor at 10 uM after 120 mins by scintillation counting analysis relative to control
SummaryPubMed CitationRelated BioAssays by Target
NK-1, NK-2 and NK-3 Calcium Flux FLIPR assays from US Patent US11149006: "Compounds as neurokinin-1 receptor antagonists and uses thereof"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding Competition Assay from US Patent US10941151: "Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof"
Assay data:29 Active, 29 Activity ≤ 1 µM, 29 Tested
Competitive Binding Assays from US Patent US10836768: "N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists"
Aequorin Assay with Human NK-3 Receptor from US Patent US10836768: "N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists"
Competitive Binding Assay from US Patent US10683295: "Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof"
3H-SB222200 Binding Competition Assay with Human NK-3 Receptor from US Patent US10544150: "NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders"
Assay data:213 Active, 179 Activity ≤ 1 µM, 221 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding Competition Assay from US Patent US9475814: "Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof"
Aequorin Functional Assay from US Patent US9475814: "Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof"
Assay data:31 Active, 31 Activity ≤ 1 µM, 31 Tested
Competitive Binding Assay from US Patent US9422299: "Substituted [1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists"
Assay data:46 Active, 46 Activity ≤ 1 µM, 46 Tested
Functional Assay from US Patent US9422299: "Substituted [1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists"
[3H]SR142801 Competition Binding Assay from US Patent US9346786: "Pyrrolidine compounds"
Assay data:122 Active, 14 Activity ≤ 1 nM, 122 Activity ≤ 1 µM, 122 Tested
Binding Assay from US Patent US8906933: "Dihydropyrimidin-2(1H)-one compounds as neurokinin-3 receptor antagonists"
Assay data:19 Active, 16 Activity ≤ 1 µM, 20 Tested
Competitive Binding Assay from US Patent US8618303: "Pyrrolidine derivatives"
Assay data:35 Active, 35 Activity ≤ 1 µM, 35 Tested
Binding Assay from US Patent US8592454: "Nitrogen-containing heterocyclic compound and use of same"
Assay data:12 Active, 11 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
Competition Binding Assay from US Patent US8507535: "Methyl-pyrrolidine ether derivatives"
Assay data:25 Active, 25 Activity ≤ 1 µM, 25 Tested
Binding Competition Assay from US Patent US9987274: "N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists"
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