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Agonist activity at TLR2/TLR1 in mouse Macrophage cell line
Assay data:29 Active, 32 Activity ≤ 1 µM, 76 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at TLR2/TLR1 in human THP-1 cells
Assay data:41 Active, 15 Activity ≤ 1 nM, 47 Activity ≤ 1 µM, 89 Tested
Agonist activity at TLR2/TLR1 (unknown origin)
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at TLR2/TLR1 (unknown origin) assessed as induction of IL-8 production relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at TLR1/TLR2 in human THP-1 derived macrophages assessed as stimulation of TNF alpha release measured for 4 hrs by ELISA based assay relative to diprovocim-1
Assay data:80 Tested
Agonist activity at TLR1/TLR2 in human THP-1 derived macrophages assessed as stimulation of TNF alpha release measured for 4 hrs by ELISA based assay
Assay data:94 Active, 53 Activity ≤ 1 nM, 93 Activity ≤ 1 µM, 94 Tested
Agonist activity at TLR1/TLR2 in human THP-1 cells assessed as induction of TLR1/TLR2 dimerization at 20 uM incubated for 12 hrs by coimmunoprecipitation method
Assay data:1 Active, 1 Tested
Agonist activity at TLR1 in HEK-Blue hTLR2 cells at 0.2 uM incubated for 24 hrs in presence of anti-hTLR1-IgG antibodies measured by Quanti-Blue based SEAP assay
TBD from US Patent US11472815: "1,4-diphenyl-1H-imidazole and 2,4-diphenylthiazole derivatives and preparation method therefor and use thereof"
Assay data:14 Active, 35 Activity ≤ 1 µM, 35 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of rhodamine-labeled Pam3CSK4 binding to TLR1 (unknown origin)/TLR2 (unknown origin) expressed in baculovirus infected sf9 cells incubated for 30 mins by fluorescence polarization assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Rho-Pam3 binding to TLR1 (unknown origin)/human TLR2 expressed in HEK293 cells incubated for 30 mins by fluorescence polarization assay
Antagonist activity at TLR1 in human PBMC assessed as inhibition of Pam3CSK4-induced TNFalpha production preincubated for 30 mins followed by Pam3CSK4 addition and measured after 20 hrs by HTRF assay
Assay data:1 Tested
Agonist activity at TLR2/1 in PMA-differentiated human THP-1 cells assessed as induction of IL-6 production at 2.5 uM incubated for 24 hrs after preincubation with anti-hTLR2-IGA for 2 hrs by ELISA
Assay data:3 Active, 6 Tested
Agonist activity at wild-type human TLR1 expressed in HEK293 cells up to 25 uM measured after 6 hrs by NF-kappaB luciferase reporter gene assay
Inhibition of PAM3CSK4-induced TLR1/2 activation in human HEK-Blue hTLR2 cells
Antagonist activity at TLR2/TLR1 in human THP1 cells assessed as reduction in diprovoci-induced TNF production at 50 uM pre-incubated for 1 hr before diprovocim stimulation for 4 hrs by ELISA method
Antagonist activity at TLR2/TLR1 in human THP1 cells assessed as reduction in diprovoci-induced TNF production at 5 uM pre-incubated for 1 hr before diprovocim stimulation for 4 hrs by ELISA method
Induction of human TLR1 homodimerization expressed in insect Hi5 cells by size exclusion chromatography
Induction of human TLR2/TLR1 heterodimerization expressed in insect Hi5 cells by size exclusion chromatography
Antagonist activity at TLR2/1 in human THP1 cells assessed as reduction in PAM3CSK4-induced IL6 secretion at 50 uM after 24 hrs by ELISA
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