Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Agonist activity at human TRPC5 stably expressed in T-REx-293 cells assessed as increase in calcium flux at 10 uM by Fura-2AM dye based fluorescence plate reader assay
Assay data:1 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at human TRPC5 stably expressed in HEK293 cells assessed as increase in calcium flux by Fura-2AM dye based fluorescence plate reader assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human TRPC5 stably expressed in T-REx-293 cells assessed as increase in calcium flux by Fura-2AM dye based fluorescence plate reader assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human TRPC5 channel expressed in HEK293 cells assessed as inhibition of EA-evoked channel current measured at +80 mV by whole-cell voltage clamp assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of TRPC5 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of EA-evoked Ca2+ entry by measuring reduction in intracellular Ca2+ level by Fluo-4 dye based FLIPR assay
Assay data:17 Active, 14 Activity ≤ 1 µM, 34 Tested
Inhibition of human TRPC5 channel expressed in HEK293 cells assessed as inhibition of EA-evoked Calcium influx by measuring reduction in intracellular Ca2+ level and measured upto 360 sec by Fluo-4/AM dye based FLIPR assay
Assay data:22 Active, 6 Activity ≤ 1 µM, 36 Tested
Patch Clamp Assay from US Patent US9447114: "Thieno- and furo[2,3-d]pyrimidine-2,4[1H,3H]-dione derivatives"
Assay data:6 Active, 4 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
High Throughput Screening Assay from US Patent US9447114: "Thieno- and furo[2,3-d]pyrimidine-2,4[1H,3H]-dione derivatives"
Assay data:23 Active, 21 Activity ≤ 1 µM, 23 Tested
TRP selectivity screen (TRPC5)
Assay data:2 Tested
SummaryRelated BioAssays by Target
Antagonist activity at human TRPC5 at <= 30 uM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human TRPC5 expressed in HEK293-T-REx cells assessed as decrease in riluzole-induced calcium response preincubated for 5 min followed by riluzole stimulation by Fluo-4 AM dye based FLIPR assay
Assay data:6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human TRPC5 expressed in HEK293 Tet cells assessed as increase in intracellular calcium level at 10 nM measured at 5 secs interval for 300 secs by Fura-2AM dye based fluorescence assay
Assay data:2 Active, 5 Tested
Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as blocking of inward/outward currents after 20 to 48 hrs in presence of LaCl3 by patch clamp assay
Assay data:6 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of TRPC5 (unknown origin) transfected in HEK293/TREx cells assessed as reduction of rise in intracellular Ca2+ concentration after 60 to 80 mins by Fluo4 cell-based fluorescence assay
Assay data:5 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of riluzole-activated human TRPC5 channel expressed in HEK293 cells measured at holding potential of -60 mV by Q-patch clamp assay
Assay data:1 Active, 1 Tested
Inhibition of human TRPC5 channel expressed in HEK293 cells incubated for 10 mins by FLIPR assay
Inhibition of (-)-Englerin-activated human TRPC5 channel expressed in HEK293 cells measured at holding potential of -60 mV by Q-patch clamp assay
Inhibition of lanthanum-activated human TRPC5 channel expressed in HEK293 cells measured at holding potential of -60 mV by Q-patch clamp assay
Inhibition of human TRPC5 channel expressed in HEK293 cells assessed as decrease in current amplitude treated for 3 mins measured between +80 mV and -80 mV by manual patch clamp assay
Inhibition of rosiglitazone-activated human TRPC5 channel expressed in HEK293 cells assessed as reduction in Ca2+ current measured at +80 mV with holding potential of -60 mV by Q-patch clamp assay
Assay data:20 Active, 9 Activity ≤ 1 µM, 40 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on