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Inhibition of TYRO3(unknown origin) at 1 uM relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of RSE (unknown origin) at 1 uM relative to control
TAM Enzymatic Assay from US Patent US11591338: "Pyrrolotriazine compounds as TAM inhibitors"
Assay data:142 Active, 144 Activity ≤ 1 µM, 144 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000542a TYRO3
SummaryRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000300bCl TYRO3
Affinity Biochemical interaction (HTRF assay) EUB0000147b TYRO3
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Affinity Biochemical interaction (Enzyme activity assay) EUB0000624a TYRO3
Affinity Phenotypic Cellular interaction (CellTiter-Glo assay (Promega, proliferation in H1703 cell line)) EUB0000147b TYRO3
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (MTT assay (Promega; inhibition of cell proliferation in Met-driven H1993 cells)) EUB0000624a TYRO3
Inhibition of TYRO3 (unknown origin)
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human RSE (451 to end residues) assessed as residual activity at 1 uM using KVEKIGEGTYGVVYK as substrate measured after 40 mins in presence of [gamma33P]ATP by radiometric scintillation counting method relative to control
Inhibition of Tyro3 (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate incubated for 180 mins in presence of ATP by microfluidic capillary electrophoresis analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
TYRO3 DiscoveRx kinase panel
Rse(h) Kinase panel
Inhibition of TYRO3 (unknown origin) at 1 uM
Inhibition of human RSE in presence of ATP by radiometric assay
Enzyme Assay from US Patent US11247990: "Bicyclic fused pyridine compounds as inhibitors of TAM kinases"
Assay data:458 Active, 508 Activity ≤ 1 µM, 508 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
TAM Enzymatic Assay from US Patent US11241438: "Formulations of an AXL/MER inhibitor"
TAM Kinase Assay from US Patent US11136326: "Pyrrolopyrimidine derivatives as TAM inhibitors"
Assay data:82 Active, 54 Activity ≤ 1 µM, 90 Tested
Enzymatic Assay from US Patent US11104682: "Salts of TAM inhibitors"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
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