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Inhibition of human wild type VCP (1 to 806 residues) expressed in Escherichia coli BL21 (DE3) incubated for 1 hr in presence of ATP by malachite green staining based analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of p97 (unknown origin) using ATP as substrate incubated for 60 mins by ADP-Glo reagent based luminescence assay
Assay data:19 Active, 16 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant p97 (unknown origin) expressed in Escherichia coli (DE3) incubated for 30 mins by malachite green based ATPase assay
Inhibition of p97 (unknown origin) in presence of ATP by Biomol Green Reagent based assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of p97 (unknown origin) incubated for 15 mins in presence of ATP by ADP Glo assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Biological Assay from US Patent US11247985: "Phenyl indole allosteric inhibitors of P97 ATPase"
Assay data:135 Active, 90 Activity ≤ 1 µM, 157 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biomol Green Assay from US Patent US10894782: "Modulators of P97 AAA ATPase activity"
Assay data:119 Active, 113 Activity ≤ 1 µM, 120 Tested
ADP Glo Assay from US Patent US9062026: "Fused pyrimidines and substituted quinazolines as inhibitors of p97"
Assay data:83 Active, 88 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of p97 (unknown origin) incubated for 60 mins by ADP-Glo assay
Assay data:23 Active, 23 Activity ≤ 1 µM, 23 Tested
Inhibition of p97 (unknown origin) expressed in HEK293 cells co-expressing TCRalpha-GFP assessed as reduction in ERAD-dependent reporter substrate TCRalpha-GFP degradation at 10 uM incubated for 60 to 120 mins by immunoblotting analysis
Irreversible inhibition of p97 in human HeLa cells assessed as reduction in p97-dependent reporter substrate UbG76V-GFP degradation preincubated followed by washout and measured after 17 hrs by luciferase reporter gene assay
Assay data:1 Active, 2 Tested
Inhibition of His6-tagged p97 C522A mutant (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ATPase activity measured after 60 mins by biomol green reagent based assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to His6-tagged p97 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as Cys522-adduct formation by tandem mass spectrometry
Inhibition of His6-tagged p97 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ATPase activity measured after 60 mins in presence of DTT by biomol green reagent based assay
Inhibition of His6-tagged p97 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ATPase activity measured after 60 mins in presence of cysteine by biomol green reagent based assay
Inhibition of p97 in human HeLa cells assessed as reduction in proteasomal turnover of p97-dependent reporter substrate UbG76V-GFP incubated for 120 mins by luciferase reporter gene assay
Assay data:20 Active, 28 Tested
Inhibition of His6-tagged p97 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ATPase activity measured after 60 mins by biomol green reagent based assay
Assay data:20 Active, 4 Activity ≤ 1 µM, 28 Tested
Competitive inhibition of recombinant human full length Avi-tagged p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2(DE3) using 20 uM ATP as substrate incubated for 90 mins by ADP-glo assay based Michaelis-Menten plot analysis
Uncompetitive inhibition of recombinant human full length Avi-tagged p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2(DE3) using 20 uM ATP as substrate incubated for 90 mins by ADP-glo assay based Michaelis-Menten plot analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of recombinant human full length Avi-tagged p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2(DE3) using 100 uM ATP as substrate incubated for 90 mins by ADP-glo assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 5 Tested
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