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Biochemical Assay from US Patent US9145380: "Bis-(sulfonylamino) derivatives for use in therapy"
Assay data:239 Active, 113 Activity ≤ 1 µM, 239 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of mPGES (unknown origin) up to 30000 nM using PGH2 as substrate measured after 90 to 120 secs by RapidFire high-throughput mass spectrometry assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to PTGES2 in human A549 cells lysates grown on SILAC media at 10 uM incubated for 1 hr by LC-MS/MS analysis relative to untreated control
Assay data:2 Tested
Binding affinity to PTGES2 in human A549 cells lysates grown on SILAC media at 10 uM incubated for 1 hr by LC-MS/MS analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of mPGES2 in A23187-stimulated human THP1 cells assessed as decrease in PGE2 production at 10 uM using arachidonic acid as substrate relative to control
Assay data:6 Tested
Inhibition of mPGES2 in human THP1 cells assessed as reduction in A23187-stimulated PGE2 production at 10 uM relative to control
Human mPGES2 (Prostaglandin synthases)
Assay data:1 Active, 1 Tested
Inhibition of human recombinant mPGES-2 expressed in CHO cells assessed as reduction in conversion of PGH2 to PGE2 at 10 uM incubated for 10 mins followed by substrate addition measured after 1 min
Inhibition of human mPGES-2
Assay data:3 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Inhibition of recombinant mPGES-2 (unknown origin) at 10 uM
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
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