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Inhibition of human calpain using Z-Phe-Arg-AMC as substrate incubated for 30 mins by FRET assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Non-covalent inhibition of Calpain 1 (unknown origin) incubated for 1 hr by FRET-based enzymatic assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Covalent inhibition of Calpain 1 (unknown origin) incubated for 1 hr by FRET-based enzymatic assay
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Calpain I (unknown origin) assessed as inhibition constant
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human Calpain I assessed as dissociation constant using Suc-Leu-Tyr-AMC as substrate preincubated for 15 mins followed by compound addition and measured after 40 mins by SDS-PAGE based HPLC analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human Calpain-1 incubated for 60 mins by Bio-Rad protein assay dye reagent based assay
Assay for the Determination of the Capacity to Inhibit Calpain 1 from US Patent US11242312: "Dipeptidyl ketoamide meta-methoxyphenyl derivatives and uses thereof"
Assay data:6 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
FRET-based enzymatic assay from Article 10.1021/jacs.1c08060: "Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity."
Assay data:25 Active, 4 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 38 Tested
Enzymatic Inhibition of UAWJ9-36-1 and UAWJ9-36-3 against the Mpro's from Seven Human Coronaviruses from Article 10.1021/acsptsci.1c00099: "Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir."
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition FRET Assay from US Patent US9403843: "Cysteine protease inhibitors and uses thereof"
Assay data:32 Active, 47 Activity ≤ 1 µM, 54 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
u-Calpain Inhibition Assay from Article 10.1016/j.bioorg.2013.09.002: "Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors."
Assay data:2 Active, 2 Activity ≤ 1 µM, 15 Tested
MU-CALPAIN Eurofins-Panlabs selectivity data (BI)
SummaryRelated BioAssays by Target
MU-CALPAIN Eurofins SafetyScreen44 (BI)
Competitive inhibition of human erythrocytes mu-calpain using varying level of Pep2 as substrate by Lineweaver-Burk plot analysis
Assay data:1 Active, 2 Tested
Inhibition of mu-calpain in human SH-SY5Y cells assessed as reduction in tau phosphorylation by Western blot analysis
Assay data:2 Active, 2 Tested
Inhibition of mu-calpain in human SH-SY5Y cells assessed as reduction in GOx-induced p25 phosphorylation pretreated with GOx for 4 hrs followed by compound treatment by Western blot analysis
Inhibition of mu-calpain in human SH-SY5Y cells assessed as reduction in GOx-induced MAPK phosphorylation pretreated with GOx for 4 hrs followed by compound treatment by Western blot analysis
Inhibition of mu-calpain (unknown origin) expressed in HEK293T cells assessed as reduction in p35 cleavage at 30 uM using p35 as substrate measured after 210 mins by fluorescence microplate reader assay
Inhibition of mu-calpain (unknown origin) expressed in HEK293T cells assessed as reduction in p35 cleavage at 100 uM using p35 as substrate measured after 210 mins by fluorescence microplate reader assay
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