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Inhibition of caspase-8 (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Caspase Activity Assay from US Patent US11447497: "(S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases"
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Fluorometric Enzymatic Assay from US Patent US9045524: "Selective caspase inhibitors and uses thereof"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme Inhibition Assay from Article 10.1021/jm900135r: "Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6."
Assay data:24 Active, 22 Activity ≤ 1 µM, 25 Tested
Caspase Inhibition Assay from Article 10.1016/j.bmcl.2003.10.064: "Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors."
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
Caspase Inhibition Assay from Article 10.1016/j.bmcl.2005.05.116: "Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors."
Assay data:29 Active, 26 Activity ≤ 1 µM, 29 Tested
Caspase Inhibition Assay from Article 10.1021/jm0506625: "N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies."
Assay data:32 Active, 32 Activity ≤ 1 µM, 32 Tested
Caspase Inhibition Assay from Article 10.1021/jm0100537: "Potent and selective nonpeptide inhibitors of caspases 3 and 7."
Assay data:26 Active, 20 Activity ≤ 1 µM, 30 Tested
Caspase Inhibition Assay from Article 10.1021/jm050896o: "Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors."
Assay data:51 Active, 49 Activity ≤ 1 µM, 51 Tested
Enzyme Inhibition Assay from Article 10.1021/jm0493212: "Discovery of a novel class of reversible non-peptide caspase inhibitors via a structure-based approach."
Assay data:1 Active, 11 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Fluorometric Assay from Article 10.1021/jm020230j: "Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design."
Assay data:42 Active, 34 Activity ≤ 1 µM, 43 Tested
Peptidase, CASP8 (Caspase 8) Eurofins-Panlabs enzyme assay
Assay data:4 Tested
SummaryRelated BioAssays by Target
Caspase-8 (h) Eurofins-Cerep enzyme and uptake assay
Assay data:1 Tested
CASPASE8_CE Eurofins SafetyScreen44 (BI)
Inhibition of Caspase 8 (unknown origin) at 100 uM
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Caspase 8 (unknown origin) at 10 uM
Assay data:3 Tested
Inhibition of recombinant human caspase 8 (217 to end residues) expressed in Escherichia coli at 10 uM using Ac-IETD-AMC as substrate after 60 mins by spectrophotometric analysis relative to control
Inhibition of caspase8 (unknown origin) using Ac-LEHD-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate reader analysis
Inhibition of human full-length recombinant caspase 8 expressed in Escherichia coli at 10 uM using Ac-IETD-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by spectrofluorimetric analysis relative to control
Inhibition of caspase-8 (unknown origin) at 10 uM
Assay data:1 Active, 1 Tested
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