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Agonist activity at GPR174 (unknown origin) transfected in HEK293FT cells after 1 hr by TGFalpha shedding assay
Assay data:27 Active, 33 Activity ≤ 1 µM, 52 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human GPR174 in anti-CD3/antiCD28-stimulated human PBMC assessed as reduction in natural Treg cells (FoxP3+Helios+) measure after 7 days by ELISA
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of human GPR174 in anti-CD3/antiCD28-stimulated human PBMC assessed as reduction in natural Treg cells (FoxP3+Helios+) at 100 uM measure after 7 days by flow cytometry
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of human GPR174 in anti-CD3/antiCD28-stimulated human PBMC assessed as increase in natural Treg cells (FoxP3+Helios-) at 100 uM measure after 7 days by flow cytometry
Allosteric modulator activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity relative to control
Assay data:6 Active, 6 Tested
Antagonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity relative to control
Assay data:7 Active, 7 Tested
Inhibition of human GPR174 in anti-CD3/antiCD28-stimulated human PBMC assessed as increase in IL-2 level measured after 2 days by ELISA
Assay data:2 Tested
Inhibition of GPR174 in anti-CD3/antiCD28-stimulated human PBMC assessed as increase in IFNgamma level measured after 2 days by ELISA
Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity
Assay data:50 Active, 23 Activity ≤ 1 µM, 50 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of GPR174 (unknown origin) in cells assessed as incorporation of nuclear localization sequence into transmembrane protein by cellular redistribution assay
Assay data:12 Active, 10 Activity ≤ 1 µM, 26 Tested
Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity relative to control
Assay data:50 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Human GPR174 (Class A Orphans)
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human GPR174 in anti-CD3/antiCD28-stimulated human PBMC assessed as increase in IL-2 production measured after 2 days
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
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