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Agonist activity at human recombinant S1P4 receptor expressed in CHO cells by GTPgammaS binding assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Late-stage fluorescence-based dose-response cell-based counterscreen assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): inhibition by S1P4-selective antagonist 1.2 nM
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds set 2
Assay data:18 Active, 16 Activity ≤ 1 µM, 31 Tested
Late-stage fluorescence dose-response cell-based counterscreen assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Sphingosine 1-Phosphate Receptor 4 (S1P4) antagonist assay Set 2
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Late-stage fluorescence-based dose-response cell-based counterscreen assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): inhibition by S1P4-selective antagonist control
Late-stage fluorescence dose response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): purchased compounds EC50
Assay data:3 Active, 41 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding at 10 uM
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at human S1P4 receptor expressed in CHO cells assessed as inhibition of S1P-induced [35S]GTPgamma binding at 10 uM
Agonist activity at human recombinant S1P4 receptor expressed in CHO cells at 10 uM by GTPgammaS binding assay relative to S1P
Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation counting
Late-stage fluorescence-based dose-response cell-based counterscreen assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): inhibition by S1P4-selective antagonist 0.4 nM
Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS binding
Assay data:8 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 9 Tested
Late-stage fluorescence dose response cell-based counterscreening assay for agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): inhibition by S1P4-selective antagonist
Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds
Assay data:9 Active, 6 Activity ≤ 1 µM, 20 Tested
Agonist activity at human SIP4 receptor at 10 uM by [35S]GTPgammaS binding assay relative to S1P
Assay data:15 Tested
Agonist activity at human SIP4 receptor by [35S]GTPgammaS binding assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 15 Tested
Ratio of agonistic Emax for S1P to compound for human S1P4 receptor by [35S]GTPgammaS binding assay
Assay data:6 Tested
Ratio of agonistic EC50 for S1P to compound for human S1P4 receptor by [35S]GTPgammaS binding assay
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