Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Selectivity interaction (Kinase panel (KiNativ method in HeLa cells)) EUB0000122b TNK1
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Selectivity interaction (Kinase panel (ATP-site competition binding assay)) EUB0000122b TNK1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (Enzymatic assay) EUB0000609a TNK1
TNK1 DiscoveRx kinase panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of TNK1 (unknown origin) at 1 uM
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to wild-type human full length TNK1 (M1 to P661 residues) expressed in bacterial expression system assessed as residual binding level at 100 nM by Kinomescan method relative to control
Inhibition Assay from US Patent US10464919: "Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same"
Assay data:103 Active, 2 Activity ≤ 1 nM, 103 Activity ≤ 1 µM, 103 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
KinomeScan assay: inhibition of TNK1
Assay data:108 Tested
Tnk1(TNK1LGY1) Takeda global kinase panel
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
TNK1 Invitrogen Lab (UK) kinase screen (BI)
Inhibition of TNK1 (unknown origin) at 0.5 uM relative to control
Inhibition of TNK1 (unknown origin) assessed as residual activity measured at 1 uM
Assay data:3 Tested
Inhibition of human TNK1 assessed as percent of control at 2000 nM by KINOMEscan assay relative to control
Inhibition of DNA-tagged human TNK1 assessed as percent of control at 50000 nM by qPCR analysis relative to control
Inhibition of human TNK1 assessed as percent of control at 1000 nM by KINOMEscan assay relative to control
Inhibition of wild-type human full length TNK1 (M1 to P661 residues) expressed in bacterial expression system assessed as residual activity at 1 uM by Kinomescan method relative to control
Inhibition of human TNK1 assessed as residual activity using poly[Glu:Tyr] (4:1) as substrate at 1 uM by [gamma-33P]-ATP assay relative to control
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on