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TIF1 SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Binding affinity to human partial length TRIM24 (P790 to P977 residues) expressed in bacterial expression system by BROMOscan assay
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to TRIM24 bromodomain (unknown origin) incubated for 60 mins by TR-FRET assay
Displacement of biotinylated JQ1 from TRIM24 bromodomain (unknown origin) incubated for 20 mins by AlphaLISA assay
PROTAC activity at TRIM24/VHL in human MOLM-13 cells assessed as degradation protein by measuring maximum efficacy measured after 24 hrs relative to control
PROTAC activity at TRIM24/VHL in human MOLM-13 cells assessed as degradation protein measured after 24 hrs
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Induction of TRIM24 degradation in HEK293FT cells assessed as maximum degradation
Induction of TRIM24 degradation in HEK293FT cells assessed as maximum degradation at 2 uM relative to control
PROTAC activity at TRIM24/VHL in human MOLM-13 cells assessed as degradation protein at 5 uM measured after 24 hrs
PROTAC activity at TRIM24/VHL in human HEK293FT cells assessed as degradation protein at 5 uM measured after 24 hrs
PROTAC activity at TRIM24/VHL (unknown origin) assessed as degradation protein
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Induction of TRIM24 degradation in HEK293FT cells assessed as maximum degradation at 5 uM relative to control
Inhibition of His-tagged TRIM24 (unknown origin) expressed in Escherichia coli BL21(DE3)pLysS competent cells using biotinylated-H3K23ac peptide as substrate incubated for 30 mins by Alphascreen assay
Binding affinity to human TRIM24 bromodomain by BROMOscan method
Selectivity interaction (BromoScan panel) EUB0000205c TRIM24
SummaryCompounds, ActiveRelated BioAssays by Target
Thermal Shift Assay. Domain: start/stop: G861-E979
Inhibition of TRIM24 (unknown origin) measured alphascreen assay
Assay data:21 Active, 2 Activity ≤ 1 µM, 39 Tested
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