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Inhibition of Cav3.3 (unknown origin) stably transfected in HEK293 cells assessed as slope factor at 10 uM incubated for 5 mins by whole cell voltage-clamp assay (Rvb = 5.3 +/- 0.6mV)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Cav3.3 (unknown origin) stably transfected in HEK293 cells assessed as V1/2 at 10 uM incubated for 5 mins by whole cell voltage-clamp assay (Rvb = -65.6 +/- 3.1mV)
Inhibition of Cav3.3 (unknown origin) stably transfected in HEK293 cells assessed as reduction inactivation time constant transient current at 10 uM incubated for 5 mins by whole cell voltage-clamp assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Cav3.3 (unknown origin) stably transfected in HEK293 cells assessed as activation time constant transient current at 10 uM incubated for 5 mins by whole cell voltage-clamp assay
Inhibition of Voltage-dependent T-type calcium channel (unknown origin) by HTS assay
Inhibition of Cav3.3 subunit 1alpha-l(unknown origin) stably transfected in HEK293 cells measured by FLIPR assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Cav3.3 (unknown origin) at holding potential (Vh) -100 mV and measured by whole-cell voltage-camp assay
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of Cav3.3 (unknown origin) at holding potential (Vh) -80 mV and measured by whole-cell voltage-camp assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of Cav3.3 in human HEK293 cells measured under hyperpolarizing conditions by FLIPR assay
Inhibition of Cav3.3 in human HEK293 cells measured by FLIPR assay
Inhibition of Cav3.3 (unknown origin) by voltage clamp assay
Inhibition of human Cav3.3 at 100 uM
Assay data:2 Tested
Inhibition of human Cav3.3 expressed in tsA-201 cells by patch clamp electrophysiology
Assay data:8 Active, 2 Activity ≤ 1 µM, 14 Tested
Inhibition of human Cav3.3 expressed in tsA-201 cells at 10uM by patch clamp electrophysiology
Assay data:14 Tested
Inhibition of VGCC (unknown origin)
Assay data:4 Active, 17 Tested
Inhibition of VGCC in human SHSY-5Y cells assessed as reduction of K+-evoked cytosolic ca2+ at 3 uM incubated for 10 mins prior to KCl addition by Fluo-4-AM probe-based fluorescence analysis
Inhibition of VGCC in human SHSY-5Y cells assessed as reduction of K+-evoked cytosolic ca2+ at 1 uM incubated for 10 mins prior to KCl addition by Fluo-4-AM probe-based fluorescence analysis
Assay data:25 Tested
Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-based fluorescence assay
Assay data:1 Active, 5 Tested
Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level at 10 uM after 10 mins by Fluo-4 dye-based fluorescence assay relative to control
Assay data:11 Tested
Inhibition of T-type calcium channel (unknown origin)
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